Gene description for Ptk7
Gene name PTK7 protein tyrosine kinase 7
Gene symbol Ptk7
Other names/aliases 8430404F20Rik
chz
mPTK7/CCK4
Species Mus musculus
 Database cross references - Ptk7
ExoCarta ExoCarta_71461
Vesiclepedia VP_71461
Entrez Gene 71461
UniProt Q8BKG3  
 Ptk7 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ptk7
Molecular Function
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IDA
    ATP binding GO:0005524 IC
    kinase activity GO:0016301 IDA
Biological Process
    establishment of planar polarity GO:0001736 IMP
    kidney development GO:0001822 IMP
    neural tube closure GO:0001843 IGI
    neural tube closure GO:0001843 IMP
    ventricular septum development GO:0003281 IMP
    axis elongation GO:0003401 IMP
    protein phosphorylation GO:0006468 IDA
    cell adhesion GO:0007155 IEA
    heart development GO:0007507 IMP
    positive regulation of neuron projection development GO:0010976 IEA
    positive regulation of neuron projection development GO:0010976 ISO
    Wnt signaling pathway GO:0016055 IEA
    cell migration GO:0016477 IEA
    cell migration GO:0016477 ISO
    actin cytoskeleton organization GO:0030036 IEA
    actin cytoskeleton organization GO:0030036 ISO
    wound healing GO:0042060 IGI
    establishment of epithelial cell apical/basal polarity GO:0045198 IMP
    convergent extension GO:0060026 IMP
    lung-associated mesenchyme development GO:0060484 IMP
    coronary vasculature development GO:0060976 IMP
    cellular response to retinoic acid GO:0071300 IEA
    cellular response to retinoic acid GO:0071300 ISO
    cochlea morphogenesis GO:0090103 IMP
    positive regulation of canonical Wnt signaling pathway GO:0090263 IEA
    positive regulation of canonical Wnt signaling pathway GO:0090263 ISO
Subcellular Localization
    plasma membrane GO:0005886 IDA
    cell-cell junction GO:0005911 IDA
    cell-cell junction GO:0005911 ISO
    membrane GO:0016020 IDA
 Experiment description of studies that identified Ptk7 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ptk7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mertk 17289
Co-fractionation Mus musculus
2 Fes  
Co-fractionation Mus musculus
3 Alk  
Co-fractionation Mus musculus
4 Fgfr1 14182
Co-fractionation Mus musculus
5 Fancd2  
Affinity Capture-MS Mus musculus
6 Mst1r  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Ptk7 is involved
No pathways found





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