Gene description for Mertk
Gene name c-mer proto-oncogene tyrosine kinase
Gene symbol Mertk
Other names/aliases Eyk
Mer
Nyk
nmf12
Species Mus musculus
 Database cross references - Mertk
ExoCarta ExoCarta_17289
Entrez Gene 17289
UniProt Q60805  
 Mertk identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Mertk
Molecular Function
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IEA
    transferase activity GO:0016740 IEA
    protein kinase activity GO:0004672 IEA
    protein tyrosine kinase activity GO:0004713 IEA
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    kinase activity GO:0016301 IEA
    ATP binding GO:0005524 IEA
    nucleotide binding GO:0000166 IEA
Biological Process
    apoptotic cell clearance GO:0043277 IMP
    secretion by cell GO:0032940 IMP
    natural killer cell differentiation GO:0001779 IGI
    phosphorylation GO:0016310 IEA
    vagina development GO:0060068 IGI
    retina development in camera-type eye GO:0060041 IMP
    negative regulation of lymphocyte activation GO:0051250 IGI
    positive regulation of phagocytosis GO:0050766 ISO
    negative regulation of leukocyte apoptotic process GO:2000107 ISO
    protein phosphorylation GO:0006468 ISO
    spermatogenesis GO:0007283 IGI
    substrate adhesion-dependent cell spreading GO:0034446 IMP
    platelet activation GO:0030168 IMP
    protein kinase B signaling GO:0043491 IGI
    phagocytosis GO:0006909 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cell GO:0005623 IMP
    intracellular GO:0005622 IGI
    membrane GO:0016020 IEA
    integral component of membrane GO:0016021 IEA
    rhabdomere GO:0016028 ISO
    extracellular space GO:0005615 ISO
    photoreceptor outer segment GO:0001750 ISO
 Experiment description of studies that identified Mertk in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Mertk
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mertk is involved
PathwayEvidenceSource
Cell surface interactions at the vascular wall IEA Reactome





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