Gene description for PPIAL4C
Gene name peptidylprolyl isomerase A (cyclophilin A)-like 4C
Gene symbol PPIAL4C
Other names/aliases COAS-2
Species Homo sapiens
 Database cross references - PPIAL4C
ExoCarta ExoCarta_653598
Vesiclepedia VP_653598
Entrez Gene 653598
HGNC 33995
UniProt A2BFH1  
 PPIAL4C identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for PPIAL4C
Molecular Function
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA
    cyclosporin A binding GO:0016018 IBA
    RNA polymerase II CTD heptapeptide repeat P3 isomerase activity GO:0140839 IEA
    RNA polymerase II CTD heptapeptide repeat P6 isomerase activity GO:0140840 IEA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    protein folding GO:0006457 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified PPIAL4C in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for PPIAL4C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DUSP9  
Affinity Capture-MS Homo sapiens
2 KRAS 3845
Negative Genetic Homo sapiens
3 LAGE3  
Affinity Capture-MS Homo sapiens
4 PPIAL4G  
Affinity Capture-MS Homo sapiens
5 MED17  
Affinity Capture-MS Homo sapiens
6 EGFR 1956
Negative Genetic Homo sapiens
7 CD151 977
Affinity Capture-MS Homo sapiens
8 SERPINB9 5272
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PPIAL4C is involved
No pathways found





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