Gene description for SLC6A13
Gene name solute carrier family 6 (neurotransmitter transporter), member 13
Gene symbol SLC6A13
Other names/aliases GAT-2
GAT2
GAT3
Species Homo sapiens
 Database cross references - SLC6A13
ExoCarta ExoCarta_6540
Vesiclepedia VP_6540
Entrez Gene 6540
HGNC 11046
MIM 615097
UniProt Q9NSD5  
 SLC6A13 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC6A13
Molecular Function
    amino acid:sodium symporter activity GO:0005283 IDA
    creatine transmembrane transporter activity GO:0005308 ISS
    gamma-aminobutyric acid:sodium:chloride symporter activity GO:0005332 IBA
    gamma-aminobutyric acid:sodium:chloride symporter activity GO:0005332 IDA
    gamma-aminobutyric acid:sodium:chloride symporter activity GO:0005332 TAS
    taurine transmembrane transporter activity GO:0005368 ISS
    taurine:sodium symporter activity GO:0005369 IEA
    protein binding GO:0005515 IPI
    monocarboxylic acid transmembrane transporter activity GO:0008028 IDA
    amino acid transmembrane transporter activity GO:0015171 IDA
    gamma-aminobutyric acid transmembrane transporter activity GO:0015185 ISS
Biological Process
    amino acid transport GO:0006865 IBA
    monocarboxylic acid transport GO:0015718 IDA
    taurine transmembrane transport GO:0015734 ISS
    creatine transmembrane transport GO:0015881 ISS
    sodium ion transmembrane transport GO:0035725 IBA
    gamma-aminobutyric acid reuptake GO:0051936 TAS
    gamma-aminobutyric acid import GO:0051939 ISS
    nitrogen compound transport GO:0071705 IDA
    nitrogen compound transport GO:0071705 ISS
    amino acid import across plasma membrane GO:0089718 IDA
    transport across blood-brain barrier GO:0150104 NAS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    basolateral plasma membrane GO:0016323 ISS
    cell projection GO:0042995 IBA
    extracellular exosome GO:0070062 HDA
    presynapse GO:0098793 IEA
 Experiment description of studies that identified SLC6A13 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC6A13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIM63  
Two-hybrid Homo sapiens
2 ATXN1 6310
Two-hybrid Homo sapiens
3 TRIM55  
Two-hybrid Homo sapiens
4 TCF7L2  
Co-localization Homo sapiens
View the network image/svg+xml



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