Gene description for SLC34A1
Gene name solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
Gene symbol SLC34A1
Other names/aliases FRTS2
NAPI-3
NPHLOP1
NPT2
NPTIIa
SLC11
SLC17A2
Species Homo sapiens
 Database cross references - SLC34A1
ExoCarta ExoCarta_6569
Entrez Gene 6569
HGNC 11019
MIM 182309
UniProt Q06495  
 SLC34A1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for SLC34A1
Molecular Function
    protein complex binding GO:0032403 IEA
    symporter activity GO:0015293 IEA
    protein homodimerization activity GO:0042803 IEA
    protein binding GO:0005515 IPI
    PDZ domain binding GO:0030165 IEA
    sodium-dependent phosphate transmembrane transporter activity GO:0015321 IDA
Biological Process
    ossification GO:0001503 IEA
    positive regulation of phosphate transmembrane transport GO:2000187 IEA
    kidney development GO:0001822 IEA
    response to magnesium ion GO:0032026 IEA
    ion transport GO:0006811 TAS
    dentinogenesis GO:0097187 IEA
    phosphate ion transport GO:0006817 IDA
    arsenate ion transmembrane transport GO:1901684 IEA
    sodium ion transport GO:0006814 IEA
    sodium-dependent phosphate transport GO:0044341 IEA
    gentamycin metabolic process GO:1901128 IEA
    response to lead ion GO:0010288 IDA
    response to vitamin A GO:0033189 IEA
    response to mercury ion GO:0046689 IDA
    response to estradiol GO:0032355 IEA
    cellular response to parathyroid hormone stimulus GO:0071374 IEA
    glycoprotein metabolic process GO:0009100 IEA
    bone remodeling GO:0046849 IEA
    tricarboxylic acid metabolic process GO:0072350 IEA
    response to growth hormone GO:0060416 IEA
    phosphate ion homeostasis GO:0055062 IDA
    response to drug GO:0042493 IEA
    transmembrane transport GO:0055085 TAS
    indole metabolic process GO:0042431 IEA
    protein homooligomerization GO:0051260 IEA
    positive regulation of membrane potential GO:0045838 IEA
    cellular response to staurosporine GO:0072734 IEA
    cellular response to metal ion GO:0071248 IEA
    positive regulation of sodium-dependent phosphate transport GO:2000120 IEA
    response to cadmium ion GO:0046686 IDA
    response to thyroid hormone GO:0097066 IEA
    response to potassium ion GO:0035864 IEA
Subcellular Localization
    brush border membrane GO:0031526 NAS
    perinuclear region of cytoplasm GO:0048471 IEA
    plasma membrane GO:0005886 TAS
    membrane-bounded vesicle GO:0031988 IEA
    integral component of plasma membrane GO:0005887 NAS
    cell surface GO:0009986 IEA
    membrane raft GO:0045121 IEA
    basolateral plasma membrane GO:0016323 IEA
    apical plasma membrane GO:0016324 IEA
    endosome GO:0005768 IEA
 Experiment description of studies that identified SLC34A1 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC34A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC9A3R1 9368
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which SLC34A1 is involved
PathwayEvidenceSource
Type II Na+/Pi cotransporters TAS Reactome





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