Gene description for Twsg1
Gene name twisted gastrulation homolog 1 (Drosophila)
Gene symbol Twsg1
Other names/aliases 1810013J15Rik
9030422N06Rik
AW552143
D17Ertd403e
Tsg
Twg
Species Mus musculus
 Database cross references - Twsg1
ExoCarta ExoCarta_65960
Entrez Gene 65960
UniProt Q9EP52  
 Twsg1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Twsg1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    salivary gland morphogenesis GO:0007435 IMP
    tissue development GO:0009888 IGI
    cell differentiation GO:0030154 IMP
    forebrain development GO:0030900 IMP
    hemopoiesis GO:0030097 IMP
    negative regulation of osteoblast differentiation GO:0045668 IDA
    negative regulation of BMP signaling pathway GO:0030514 IMP
    camera-type eye development GO:0043010 IGI
    mesoderm formation GO:0001707 IGI
    multicellular organismal development GO:0007275 IEA
    BMP signaling pathway GO:0030509 IGI
    embryo development GO:0009790 IMP
    ossification GO:0001503 IMP
    positive regulation of BMP signaling pathway GO:0030513 IMP
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified Twsg1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Twsg1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Twsg1 is involved
No pathways found





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