Gene description for Ifitm3
Gene name interferon induced transmembrane protein 3
Gene symbol Ifitm3
Other names/aliases 1110004C05Rik
Cd225
Cdw217
DSPA2b
Fgls
IP15
mil-1
Species Mus musculus
 Database cross references - Ifitm3
ExoCarta ExoCarta_66141
Vesiclepedia VP_66141
Entrez Gene 66141
UniProt Q9CQW9  
 Ifitm3 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ifitm3
Biological Process
    immune system process GO:0002376 IEA
    innate immune response GO:0045087 IEA
    type I interferon signaling pathway GO:0060337 IDA
    negative regulation of cell proliferation GO:0008285 IDA
    receptor-mediated endocytosis GO:0006898 IMP
    response to interferon-beta GO:0035456 ISO
    defense response to virus GO:0051607 IMP
    response to interferon-alpha GO:0035455 ISO
    response to interferon-gamma GO:0034341 ISO
    response to virus GO:0009615 ISO
    response to biotic stimulus GO:0009607 IEA
    negative regulation of viral entry into host cell GO:0046597 ISO
    negative regulation of viral transcription GO:0032897 ISO
    negative regulation of viral genome replication GO:0045071 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    nucleus GO:0005634 IDA
    membrane GO:0016020 IEA
    cytoplasmic membrane-bounded vesicle GO:0016023 IDA
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 ISO
    cell surface GO:0009986 IDA
    endosome GO:0005768 IEA
    apical part of cell GO:0045177 IDA
    endoplasmic reticulum GO:0005783 IDA
    integral component of membrane GO:0016021 IEA
    lysosome GO:0005764 IEA
 Experiment description of studies that identified Ifitm3 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ifitm3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ifitm3 is involved
PathwayEvidenceSource
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell IEA Reactome





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