Gene description for Flnc
Gene name filamin C, gamma
Gene symbol Flnc
Other names/aliases 1110055E19Rik
ABP-280
ABPL
Fln2
Species Mus musculus
 Database cross references - Flnc
ExoCarta ExoCarta_68794
Vesiclepedia VP_68794
Entrez Gene 68794
UniProt Q8VHX6  
 Flnc identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Flnc
Molecular Function
    actin binding GO:0003779 TAS
    cytoskeletal protein binding GO:0008092 ISO
    ankyrin binding GO:0030506 IEA
    ankyrin binding GO:0030506 ISO
    identical protein binding GO:0042802 ISO
    actin filament binding GO:0051015 IEA
Biological Process
    actin filament-based process GO:0030029 TAS
    sarcomere organization GO:0045214 ISO
    sarcomere organization GO:0045214 ISS
    muscle cell development GO:0055001 IDA
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 ISO
    actin cytoskeleton GO:0015629 TAS
    sarcoplasm GO:0016528 IEA
    sarcoplasm GO:0016528 ISO
    Z disc GO:0030018 IEA
    sarcolemma GO:0042383 IEA
    sarcolemma GO:0042383 ISO
    intercellular bridge GO:0045171 IEA
    intercellular bridge GO:0045171 ISO
 Experiment description of studies that identified Flnc in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Flnc
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sgcd  
Co-fractionation Mus musculus
2 Rnf123  
Affinity Capture-MS Mus musculus
3 Elf5  
Affinity Capture-MS Mus musculus
4 Nphp4  
Affinity Capture-MS Mus musculus
5 Kctd13  
Affinity Capture-MS Mus musculus
6 Trim63  
Affinity Capture-MS Mus musculus
7 Myoz1  
Co-fractionation Mus musculus
8 Nphp1  
Affinity Capture-MS Mus musculus
9 Iqcb1  
Affinity Capture-MS Mus musculus
10 Fancd2  
Affinity Capture-MS Mus musculus
11 Mettl21e  
Affinity Capture-MS Mus musculus
12 Phldb2 208177
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Flnc is involved
PathwayEvidenceSource
Cell junction organization IEA Reactome
Cell-Cell communication IEA Reactome
Cell-extracellular matrix interactions IEA Reactome





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