Gene description for Flnc
Gene name filamin C, gamma
Gene symbol Flnc
Other names/aliases 1110055E19Rik
ABP-280
ABPL
Fln2
Species Mus musculus
 Database cross references - Flnc
ExoCarta ExoCarta_68794
Entrez Gene 68794
UniProt Q8VHX6  
 Flnc identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Flnc
Molecular Function
    actin filament binding GO:0051015 IEA
    actin binding GO:0003779 TAS
    ankyrin binding GO:0030506 ISO
    cytoskeletal protein binding GO:0008092 ISO
Biological Process
    actin filament-based process GO:0030029 TAS
    muscle fiber development GO:0048747 IDA
Subcellular Localization
    sarcoplasm GO:0016528 ISO
    cytoskeleton GO:0005856 IEA
    membrane GO:0016020 IEA
    actin cytoskeleton GO:0015629 TAS
    cytoplasm GO:0005737 ISO
    sarcolemma GO:0042383 ISO
    plasma membrane GO:0005886 ISO
    focal adhesion GO:0005925 ISO
 Experiment description of studies that identified Flnc in exosomes
1
Experiment ID 210
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Flnc
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Flnc is involved
PathwayEvidenceSource
Cell-extracellular matrix interactions IEA Reactome





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