Gene description for TBXAS1
Gene name thromboxane A synthase 1 (platelet)
Gene symbol TBXAS1
Other names/aliases BDPLT14
CYP5
CYP5A1
GHOSAL
THAS
TS
TXAS
TXS
Species Homo sapiens
 Database cross references - TBXAS1
ExoCarta ExoCarta_6916
Vesiclepedia VP_6916
Entrez Gene 6916
HGNC 11609
MIM 274180
UniProt P24557  
 TBXAS1 identified in sEVs derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for TBXAS1
Molecular Function
    monooxygenase activity GO:0004497 IEA
    thromboxane-A synthase activity GO:0004796 IBA
    thromboxane-A synthase activity GO:0004796 IDA
    thromboxane-A synthase activity GO:0004796 IMP
    thromboxane-A synthase activity GO:0004796 TAS
    iron ion binding GO:0005506 IEA
    protein binding GO:0005515 IPI
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 IEA
    heme binding GO:0020037 IDA
    12-hydroxyheptadecatrienoic acid synthase activity GO:0036134 TAS
    hydroperoxy icosatetraenoate dehydratase activity GO:0106256 IDA
Biological Process
    prostaglandin biosynthetic process GO:0001516 IMP
    icosanoid metabolic process GO:0006690 IDA
    icosanoid metabolic process GO:0006690 TAS
    cyclooxygenase pathway GO:0019371 TAS
    intracellular chloride ion homeostasis GO:0030644 IEA
    response to ethanol GO:0045471 IEA
    positive regulation of vasoconstriction GO:0045907 IEA
    response to fatty acid GO:0070542 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    cytosol GO:0005829 IDA
 Experiment description of studies that identified TBXAS1 in sEVs
1
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TBXAS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EEF1A2 1917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 UBC 7316
Reconstituted Complex Homo sapiens
View the network image/svg+xml



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