Gene description for UPK3A
Gene name uroplakin 3A
Gene symbol UPK3A
Other names/aliases UP3A
UPIII
UPIIIA
UPK3
Species Homo sapiens
 Database cross references - UPK3A
ExoCarta ExoCarta_7380
Entrez Gene 7380
HGNC 12580
MIM 611559
UniProt O75631  
 UPK3A identified in exosomes derived from the following tissue/cell type
Urine 19056867    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for UPK3A
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    kidney development GO:0001822 IEA
    potassium ion homeostasis GO:0055075 IEA
    urea transport GO:0015840 IEA
    epithelial cell differentiation GO:0030855 IDA
    cell morphogenesis GO:0000902 IEA
    sodium ion homeostasis GO:0055078 IEA
    urinary bladder development GO:0060157 IEA
    water transport GO:0006833 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    integral component of membrane GO:0016021 IEA
    apical plasma membrane GO:0016324 IEA
 Experiment description of studies that identified UPK3A in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
2
Experiment ID 196
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 197
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UPK3A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UPK1B 7348
Invivo Homo sapiens
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which UPK3A is involved
No pathways found





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