Gene description for UPK3A
Gene name uroplakin 3A
Gene symbol UPK3A
Other names/aliases UP3A
UPIII
UPIIIA
UPK3
Species Homo sapiens
 Database cross references - UPK3A
ExoCarta ExoCarta_7380
Vesiclepedia VP_7380
Entrez Gene 7380
HGNC 12580
MIM 611559
UniProt O75631  
 UPK3A identified in sEVs derived from the following tissue/cell type
Urine 19056867    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for UPK3A
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cell morphogenesis GO:0000902 IEA
    kidney development GO:0001822 IEA
    water transport GO:0006833 IBA
    urea transport GO:0015840 IBA
    epithelial cell differentiation GO:0030855 IDA
    potassium ion homeostasis GO:0055075 IEA
    sodium ion homeostasis GO:0055078 IEA
    urinary bladder development GO:0060157 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 IBA
    extracellular exosome GO:0070062 HDA
    apical plasma membrane urothelial plaque GO:0120001 IEA
 Experiment description of studies that identified UPK3A in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
2
Experiment ID 196
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 197
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UPK3A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SGTA 6449
Two-hybrid Homo sapiens
2 UPK1B 7348
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which UPK3A is involved
No pathways found





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