Gene description for Rap2b
Gene name RAP2B, member of RAS oncogene family
Gene symbol Rap2b
Other names/aliases 4021402C18Rik
Species Mus musculus
 Database cross references - Rap2b
ExoCarta ExoCarta_74012
Entrez Gene 74012
UniProt P61226  
 Rap2b identified in exosomes derived from the following tissue/cell type
Mov neuroglial cells 15210972    
 Gene ontology annotations for Rap2b
Molecular Function
    protein domain specific binding GO:0019904 IPI
    GTP binding GO:0005525 ISO
    nucleotide binding GO:0000166 IEA
    GDP binding GO:0019003 ISO
Biological Process
    platelet activation GO:0030168 ISO
    positive regulation of protein autophosphorylation GO:0031954 IDA
    signal transduction GO:0007165 IEA
    small GTPase mediated signal transduction GO:0007264 IEA
    platelet aggregation GO:0070527 ISO
    Rap protein signal transduction GO:0032486 IDA
    negative regulation of cell migration GO:0030336 IDA
    regulation of protein tyrosine kinase activity GO:0061097 IDA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    cytosol GO:0005829 ISO
    cell-cell contact zone GO:0044291 ISO
    recycling endosome membrane GO:0055038 IDA
    plasma membrane GO:0005886 ISO
    recycling endosome GO:0055037 IDA
    endosome GO:0005768 IEA
    membrane raft GO:0045121 ISO
    bicellular tight junction GO:0005923 ISO
    membrane GO:0016020 ISO
 Experiment description of studies that identified Rap2b in exosomes
Experiment ID 39
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Rap2b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rap2b is involved
No pathways found

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