Gene description for Lonp1
Gene name lon peptidase 1, mitochondrial
Gene symbol Lonp1
Other names/aliases 1200017E13Rik
LON
Prss15
Species Mus musculus
 Database cross references - Lonp1
ExoCarta ExoCarta_74142
Entrez Gene 74142
UniProt Q8CGK3  
 Lonp1 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Lonp1
Molecular Function
    ATPase activity GO:0016887 IDA
    mitochondrial heavy strand promoter anti-sense binding GO:0070362 IDA
    mitochondrial heavy strand promoter sense binding GO:0070364 IDA
    ATP-dependent peptidase activity GO:0004176 ISO
    serine-type peptidase activity GO:0008236 IEA
    single-stranded RNA binding GO:0003727 ISO
    single-stranded DNA binding GO:0003697 IDA
    DNA binding GO:0003677 IEA
    nucleotide binding GO:0000166 IEA
    sequence-specific DNA binding GO:0043565 ISO
    hydrolase activity GO:0016787 IEA
    ATP binding GO:0005524 ISO
    DNA polymerase binding GO:0070182 ISO
    G-quadruplex DNA binding GO:0051880 ISO
    mitochondrial light strand promoter anti-sense binding GO:0070361 ISO
    ADP binding GO:0043531 ISO
    peptidase activity GO:0008233 IEA
    mitochondrial light strand promoter sense binding GO:0070363 IDA
    serine-type endopeptidase activity GO:0004252 IEA
Biological Process
    mitochondrion organization GO:0007005 ISO
    cellular protein complex assembly GO:0043623 ISO
    oxidation-dependent protein catabolic process GO:0070407 ISO
    protein homooligomerization GO:0051260 ISO
    misfolded or incompletely synthesized protein catabolic process GO:0006515 IBA
    chaperone-mediated protein complex assembly GO:0051131 IBA
    cellular response to oxidative stress GO:0034599 ISO
    proteolysis GO:0006508 ISO
    proteolysis involved in cellular protein catabolic process GO:0051603 ISO
    protein catabolic process GO:0030163 IEA
Subcellular Localization
    mitochondrial matrix GO:0005759 ISO
    mitochondrion GO:0005739 ISO
    cytoplasm GO:0005737 ISO
    mitochondrial nucleoid GO:0042645 ISO
    membrane GO:0016020 ISO
 Experiment description of studies that identified Lonp1 in exosomes
1
Experiment ID 263
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Lonp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lonp1 is involved
No pathways found





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