Gene description for VEGFC
Gene name vascular endothelial growth factor C
Gene symbol VEGFC
Other names/aliases Flt4-L
LMPH1D
VRP
Species Homo sapiens
 Database cross references - VEGFC
ExoCarta ExoCarta_7424
Entrez Gene 7424
HGNC 12682
MIM 601528
UniProt P49767  
 VEGFC identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for VEGFC
Molecular Function
    growth factor activity GO:0008083 IEA
    protein binding GO:0005515 IPI
    vascular endothelial growth factor receptor 3 binding GO:0043185 IEA
    chemoattractant activity GO:0042056 IDA
Biological Process
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
    induction of positive chemotaxis GO:0050930 IDA
    angiogenesis GO:0001525 IEA
    positive regulation of mast cell chemotaxis GO:0060754 IDA
    substrate-dependent cell migration GO:0006929 TAS
    positive regulation of blood vessel endothelial cell migration GO:0043536 IEA
    negative regulation of blood pressure GO:0045776 IEA
    positive regulation of angiogenesis GO:0045766 IEA
    morphogenesis of embryonic epithelium GO:0016331 IEA
    positive regulation of lymphangiogenesis GO:1901492 IEA
    response to drug GO:0042493 IEA
    positive regulation of protein secretion GO:0050714 IEA
    positive regulation of cell-matrix adhesion GO:0001954 IEA
    positive regulation of cell proliferation GO:0008284 TAS
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA
    positive regulation of protein autophosphorylation GO:0031954 IEA
    positive regulation of cell division GO:0051781 IEA
    regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 IEA
    positive regulation of epithelial cell proliferation GO:0050679 IEA
    signal transduction GO:0007165 TAS
    platelet activation GO:0030168 TAS
    positive regulation of neuroblast proliferation GO:0002052 IEA
    organ morphogenesis GO:0009887 IEA
    negative regulation of cell proliferation GO:0008285 IEA
    positive chemotaxis GO:0050918 IDA
    platelet degranulation GO:0002576 TAS
    blood coagulation GO:0007596 TAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    membrane GO:0016020 IEA
    platelet alpha granule lumen GO:0031093 TAS
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified VEGFC in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for VEGFC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FLT4  
Affinity Capture-Western Homo sapiens
2 VEGFC 7424
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
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