Gene description for VEGFC
Gene name vascular endothelial growth factor C
Gene symbol VEGFC
Other names/aliases Flt4-L
LMPH1D
VRP
Species Homo sapiens
 Database cross references - VEGFC
ExoCarta ExoCarta_7424
Vesiclepedia VP_7424
Entrez Gene 7424
HGNC 12682
MIM 601528
UniProt P49767  
 VEGFC identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for VEGFC
Molecular Function
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IBA
    chemoattractant activity GO:0042056 IBA
    chemoattractant activity GO:0042056 IDA
    vascular endothelial growth factor receptor 3 binding GO:0043185 IBA
    vascular endothelial growth factor receptor 3 binding GO:0043185 IPI
Biological Process
    response to hypoxia GO:0001666 IBA
    sprouting angiogenesis GO:0002040 IBA
    positive regulation of neuroblast proliferation GO:0002052 IEA
    substrate-dependent cell migration GO:0006929 TAS
    signal transduction GO:0007165 TAS
    positive regulation of cell population proliferation GO:0008284 TAS
    response to xenobiotic stimulus GO:0009410 IEA
    animal organ morphogenesis GO:0009887 IEA
    glial cell proliferation GO:0014009 IEA
    morphogenesis of embryonic epithelium GO:0016331 IEA
    regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 IEA
    vascular endothelial growth factor signaling pathway GO:0038084 IBA
    positive regulation of blood vessel endothelial cell migration GO:0043536 IEA
    negative regulation of osteoblast differentiation GO:0045668 IEA
    positive regulation of angiogenesis GO:0045766 IEA
    negative regulation of blood pressure GO:0045776 IEA
    vascular endothelial growth factor receptor signaling pathway GO:0048010 IBA
    vascular endothelial growth factor receptor signaling pathway GO:0048010 IDA
    positive regulation of epithelial cell proliferation GO:0050679 IEA
    positive regulation of protein secretion GO:0050714 IEA
    positive chemotaxis GO:0050918 IEA
    induction of positive chemotaxis GO:0050930 IBA
    induction of positive chemotaxis GO:0050930 IDA
    positive regulation of cell division GO:0051781 IEA
    positive regulation of glial cell proliferation GO:0060252 IEA
    positive regulation of mast cell chemotaxis GO:0060754 IBA
    positive regulation of mast cell chemotaxis GO:0060754 IDA
    positive regulation of lymphangiogenesis GO:1901492 IEA
    positive regulation of mesenchymal stem cell proliferation GO:1902462 IEA
    cellular response to leukemia inhibitory factor GO:1990830 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    membrane GO:0016020 IEA
    platelet alpha granule lumen GO:0031093 TAS
 Experiment description of studies that identified VEGFC in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for VEGFC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SGTB  
Two-hybrid Homo sapiens
2 FLT4  
Affinity Capture-Western Homo sapiens
3 VEGFC 7424
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
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