Gene description for HSP90AB1
Gene name heat shock protein 90kDa alpha (cytosolic), class B member 1
Gene symbol HSP90AB1
Other names/aliases HSPCB
Species Bos taurus
 Database cross references - HSP90AB1
ExoCarta ExoCarta_767874
Vesiclepedia VP_767874
Entrez Gene 767874
UniProt Q76LV1  
 HSP90AB1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
Serum 19327352    
 Gene ontology annotations for HSP90AB1
Molecular Function
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
    unfolded protein binding GO:0051082 IEA
    disordered domain specific binding GO:0097718 IEA
    ATP-dependent protein folding chaperone GO:0140662 IEA
Biological Process
    protein folding GO:0006457 IEA
    cellular response to heat GO:0034605 IEA
    protein stabilization GO:0050821 IEA
Subcellular Localization
    cytosol GO:0005829 IEA
    plasma membrane GO:0005886 IEA
    protein-containing complex GO:0032991 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified HSP90AB1 in exosomes
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 187
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HSP90AB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AIPL1  
Two-hybrid Homo sapiens
2 MAP3K5  
Affinity Capture-Western Bos taurus
Affinity Capture-Western Bos taurus
3 AKT1  
Affinity Capture-Western Bos taurus
Affinity Capture-Western Bos taurus
4 WASL 8976
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which HSP90AB1 is involved
PathwayEvidenceSource
Aryl hydrocarbon receptor signalling IEA Reactome
Attenuation phase IEA Reactome
Axon guidance IEA Reactome
Biological oxidations IEA Reactome
Cellular response to heat stress IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta IEA Reactome
Developmental Biology IEA Reactome
ESR-mediated signaling IEA Reactome
Estrogen-dependent gene expression IEA Reactome
Fcgamma receptor (FCGR) dependent phagocytosis IEA Reactome
HSF1 activation IEA Reactome
HSF1-dependent transactivation IEA Reactome
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand IEA Reactome
Immune System IEA Reactome
Inflammasomes IEA Reactome
Innate Immune System IEA Reactome
Metabolism IEA Reactome
Nervous system development IEA Reactome
Neutrophil degranulation IEA Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways IEA Reactome
Phase I - Functionalization of compounds IEA Reactome
Regulation of actin dynamics for phagocytic cup formation IEA Reactome
RHO GTPase cycle IEA Reactome
RHOBTB GTPase Cycle IEA Reactome
RHOBTB2 GTPase cycle IEA Reactome
Sema3A PAK dependent Axon repulsion IEA Reactome
Semaphorin interactions IEA Reactome
Signal Transduction IEA Reactome
Signaling by Nuclear Receptors IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
The NLRP3 inflammasome IEA Reactome





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