Gene description for Chmp5
Gene name charged multivesicular body protein 5
Gene symbol Chmp5
Other names/aliases 2210412K09Rik
AW545668
Species Mus musculus
 Database cross references - Chmp5
ExoCarta ExoCarta_76959
Entrez Gene 76959
UniProt Q9D7S9  
 Chmp5 identified in exosomes derived from the following tissue/cell type
Embryonic fibroblasts 18494037    
 Gene ontology annotations for Chmp5
Molecular Function
    molecular_function GO:0003674 ND
Biological Process
    mitotic metaphase plate congression GO:0007080 ISO
    multivesicular body sorting pathway GO:0071985 ISO
    lysosome organization GO:0007040 IMP
    protein transport GO:0015031 IEA
    nucleus organization GO:0006997 ISO
    regulation of centrosome duplication GO:0010824 ISO
    transport GO:0006810 IEA
    vacuolar transport GO:0007034 IEA
    endosome to lysosome transport GO:0008333 IMP
    regulation of receptor recycling GO:0001919 IMP
    viral budding GO:0046755 ISO
    cell separation after cytokinesis GO:0000920 ISO
    regulation of mitotic spindle assembly GO:1901673 ISO
Subcellular Localization
    cytoplasm GO:0005737 IEA
    membrane GO:0016020 IEA
    intracellular GO:0005622 IMP
    extracellular exosome GO:0070062 ISO
    endosome GO:0005768 IEA
    cytosol GO:0005829 ISO
    nucleus GO:0005634 IDA
    cell GO:0005623 IMP
 Experiment description of studies that identified Chmp5 in exosomes
1
Experiment ID 73
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSP70|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 18494037    
Organism Mus musculus
Experiment description Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes.
Authors Ji H, Erfani N, Tauro BJ, Kapp EA, Zhu HJ, Moritz RL, Lim JW, Simpson RJ
Journal name ELEC
Publication year 2008
Sample Embryonic fibroblasts
Sample name NIH3T3
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA]
Western blotting
 Protein-protein interactions for Chmp5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Chmp5 is involved
PathwayEvidenceSource
Endosomal Sorting Complex Required For Transport (ESCRT) IEA Reactome





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