Gene description for CACNA1S
Gene name calcium channel, voltage-dependent, L type, alpha 1S subunit
Gene symbol CACNA1S
Other names/aliases CACNL1A3
CCHL1A3
Cav1.1
HOKPP
HOKPP1
MHS5
TTPP1
hypoPP
Species Homo sapiens
 Database cross references - CACNA1S
ExoCarta ExoCarta_779
Entrez Gene 779
HGNC 1397
MIM 114208
UniProt Q13698  
 CACNA1S identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for CACNA1S
Molecular Function
    high voltage-gated calcium channel activity GO:0008331 IDA
    metal ion binding GO:0046872 IEA
    voltage-gated calcium channel activity GO:0005245 IDA
    protein binding GO:0005515 IPI
Biological Process
    axon guidance GO:0007411 TAS
    calcium ion transmembrane transport GO:0070588 IEA
    skeletal muscle fiber development GO:0048741 IEA
    muscle contraction GO:0006936 IMP
    skeletal muscle adaptation GO:0043501 IEA
    neuromuscular junction development GO:0007528 IEA
    endoplasmic reticulum organization GO:0007029 IEA
    extraocular skeletal muscle development GO:0002074 IEA
    skeletal system development GO:0001501 IEA
    regulation of ion transmembrane transport GO:0034765 IEA
    myoblast fusion GO:0007520 IEA
    striated muscle contraction GO:0006941 IEA
    membrane depolarization during action potential GO:0086010 IBA
    calcium ion import GO:0070509 IBA
    calcium ion transport GO:0006816 IDA
    ion transmembrane transport GO:0034220 IBA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
    T-tubule GO:0030315 IDA
    sarcoplasmic reticulum GO:0016529 IEA
    I band GO:0031674 IDA
    voltage-gated calcium channel complex GO:0005891 IDA
 Experiment description of studies that identified CACNA1S in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for CACNA1S
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SRI 6717
Invitro Homo sapiens
2 RYR1 6261
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which CACNA1S is involved
PathwayEvidenceSource
NCAM1 interactions TAS Reactome





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