Gene description for C22orf46
Gene name chromosome 22 open reading frame 46
Gene symbol C22orf46
Other names/aliases -
Species Homo sapiens
 Database cross references - C22orf46
ExoCarta ExoCarta_79640
Vesiclepedia VP_79640
Entrez Gene 79640
HGNC 26294
UniProt C9J442  
 C22orf46 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for C22orf46
 Experiment description of studies that identified C22orf46 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for C22orf46
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 SMAD2 4087
Two-hybrid Homo sapiens
3 KRT40  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which C22orf46 is involved
No pathways found





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