Gene description for STEAP4
Gene name STEAP family member 4
Gene symbol STEAP4
Other names/aliases STAMP2
TIARP
TNFAIP9
Species Homo sapiens
 Database cross references - STEAP4
ExoCarta ExoCarta_79689
Entrez Gene 79689
HGNC 21923
MIM 611098
UniProt Q687X5  
 STEAP4 identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for STEAP4
Molecular Function
    ferric-chelate reductase (NADPH) activity GO:0052851 IBA
    cupric reductase activity GO:0008823 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    oxidation-reduction process GO:0055114 IBA
    ferric iron import into cell GO:0097461 IBA
    copper ion import GO:0015677 IBA
    iron ion homeostasis GO:0055072 IEA
    fat cell differentiation GO:0045444 ISS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 ISS
    Golgi membrane GO:0000139 IEA
    integral component of plasma membrane GO:0005887 IBA
    endosome GO:0005768 IEA
 Experiment description of studies that identified STEAP4 in exosomes
1
Experiment ID 193
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
PHB
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for STEAP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which STEAP4 is involved
No pathways found





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