Gene description for Trim2
Gene name tripartite motif-containing 2
Gene symbol Trim2
Other names/aliases mKIAA0517
narf
Species Mus musculus
 Database cross references - Trim2
ExoCarta ExoCarta_80890
Vesiclepedia VP_80890
Entrez Gene 80890
UniProt Q9ESN6  
 Trim2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Trim2
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 NAS
    myosin binding GO:0017022 NAS
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IDA
Biological Process
    protein polyubiquitination GO:0000209 IBA
    protein ubiquitination GO:0016567 IEA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    regulation of neuron apoptotic process GO:0043523 IMP
    regulation of neuron apoptotic process GO:0043523 ISO
    cellular response to leukemia inhibitory factor GO:1990830 IEP
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 NAS
 Experiment description of studies that identified Trim2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Trim2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ube2h  
Co-fractionation Mus musculus
2 Bcl2l11  
Affinity Capture-Western Mus musculus
3 Ube2k 53323
Co-fractionation Mus musculus
4 Tia1  
Affinity Capture-MS Mus musculus
5 Ube2d3  
Co-fractionation Mus musculus
6 Ube2e3  
Co-fractionation Mus musculus
7 Nefl  
Reconstituted Complex Mus musculus
8 Trim2 80890
Biochemical Activity Mus musculus
Biochemical Activity Mus musculus
View the network image/svg+xml
 Pathways in which Trim2 is involved
No pathways found





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