Gene description for Gnrhr
Gene name gonadotropin releasing hormone receptor
Gene symbol Gnrhr
Other names/aliases GH1
Lhrhr
Species Rattus norvegicus
 Database cross references - Gnrhr
ExoCarta ExoCarta_81668
Vesiclepedia VP_81668
Entrez Gene 81668
UniProt P30969  
 Gnrhr identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Gnrhr
Molecular Function
    gonadotropin-releasing hormone receptor activity GO:0004968 IBA
    gonadotropin-releasing hormone receptor activity GO:0004968 IEA
    gonadotropin-releasing hormone receptor activity GO:0004968 ISO
    protein binding GO:0005515 IPI
    growth hormone-releasing hormone receptor activity GO:0016520 IDA
Biological Process
    G protein-coupled receptor signaling pathway GO:0007186 IBA
    G protein-coupled receptor signaling pathway GO:0007186 IDA
    G protein-coupled receptor signaling pathway GO:0007186 IEA
    circadian rhythm GO:0007623 IEP
    negative regulation of cell population proliferation GO:0008285 IDA
    cellular response to hormone stimulus GO:0032870 IBA
    cellular response to gonadotropin-releasing hormone GO:0097211 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified Gnrhr in sEVs
1
Experiment ID 92
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|GAPDH|CD9|CD151
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|GAPDH|CD9|CD151
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Gnrhr
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Arrb1  
FRET Rattus norvegicus
2 Gnrhr 81668
FRET Rattus norvegicus
FRET Rattus norvegicus
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