Gene description for RAB6C
Gene name RAB6C, member RAS oncogene family
Gene symbol RAB6C
Other names/aliases WTH3
Species Homo sapiens
 Database cross references - RAB6C
ExoCarta ExoCarta_84084
Entrez Gene 84084
HGNC 16525
MIM 612909
UniProt Q9H0N0  
 RAB6C identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Thymus 23844026    
 Gene ontology annotations for RAB6C
Molecular Function
    GTPase activity GO:0003924 IDA
    GTP binding GO:0005525 IEA
Biological Process
    intracellular protein transport GO:0006886 IBA
    cell cycle process GO:0022402 IMP
    response to drug GO:0042493 IDA
    retrograde vesicle-mediated transport, Golgi to ER GO:0006890 IBA
    intra-Golgi vesicle-mediated transport GO:0006891 IBA
    Rab protein signal transduction GO:0032482 IBA
    small GTPase mediated signal transduction GO:0007264 TAS
    metabolic process GO:0008152 IDA
    retrograde transport, endosome to Golgi GO:0042147 IBA
    regulation of centrosome duplication GO:0010824 IMP
Subcellular Localization
    intracellular GO:0005622 IC
    centrosome GO:0005813 IDA
    nucleus GO:0005634 IEA
    Golgi apparatus GO:0005794 IBA
 Experiment description of studies that identified RAB6C in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RAB6C
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RAB6C is involved
No pathways found





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