Gene description for ABCC11
Gene name ATP-binding cassette, sub-family C (CFTR/MRP), member 11
Gene symbol ABCC11
Other names/aliases EWWD
MRP8
WW
Species Homo sapiens
 Database cross references - ABCC11
ExoCarta ExoCarta_85320
Vesiclepedia VP_85320
Entrez Gene 85320
HGNC 14639
MIM 607040
UniProt Q96J66  
 ABCC11 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ABCC11
Molecular Function
    ATP binding GO:0005524 IEA
    organic anion transmembrane transporter activity GO:0008514 IBA
    organic anion transmembrane transporter activity GO:0008514 IDA
    ABC-type xenobiotic transporter activity GO:0008559 IDA
    purine nucleotide transmembrane transporter activity GO:0015216 IBA
    purine nucleotide transmembrane transporter activity GO:0015216 IDA
    ABC-type glutathione S-conjugate transporter activity GO:0015431 IDA
    ABC-type bile acid transporter activity GO:0015432 IDA
    ATP hydrolysis activity GO:0016887 IEA
    ATPase-coupled transmembrane transporter activity GO:0042626 IBA
    ATPase-coupled inorganic anion transmembrane transporter activity GO:0043225 TAS
Biological Process
    organic anion transport GO:0015711 IBA
    organic anion transport GO:0015711 IDA
    bile acid and bile salt transport GO:0015721 IDA
    purine nucleotide transport GO:0015865 IDA
    xenobiotic transport GO:0042908 IDA
    transmembrane transport GO:0055085 IBA
    transmembrane transport GO:0055085 TAS
    leukotriene transport GO:0071716 IDA
    monoatomic anion transmembrane transport GO:0098656 IEA
Subcellular Localization
    vacuolar membrane GO:0005774 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    apical plasma membrane GO:0016324 IDA
    cytoplasmic vesicle membrane GO:0030659 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified ABCC11 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ABCC11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CTNNB1 1499
Co-localization Homo sapiens
2 ABCC12  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ABCC11 is involved
PathwayEvidenceSource
ABC-family proteins mediated transport TAS Reactome
Transport of small molecules TAS Reactome





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