Gene description for ABCC11
Gene name ATP-binding cassette, sub-family C (CFTR/MRP), member 11
Gene symbol ABCC11
Other names/aliases EWWD
MRP8
WW
Species Homo sapiens
 Database cross references - ABCC11
ExoCarta ExoCarta_85320
Vesiclepedia VP_85320
Entrez Gene 85320
HGNC 14639
MIM 607040
UniProt Q96J66  
 ABCC11 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ABCC11
Molecular Function
    ATP binding GO:0005524 IEA
    ATPase activity, coupled to transmembrane movement of substances GO:0042626 IEA
    purine nucleotide transmembrane transporter activity GO:0015216 IDA
    organic anion transmembrane transporter activity GO:0008514 IDA
Biological Process
    organic anion transport GO:0015711 IDA
    metabolic process GO:0008152 IEA
    purine nucleotide transport GO:0015865 IDA
    transmembrane transport GO:0055085 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 IDA
 Experiment description of studies that identified ABCC11 in exosomes
1
Experiment ID 63
MISEV standards
✘ EV Biophysical techniques
✔
AQP2
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ABCC11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ABCC11 is involved
PathwayEvidenceSource
ABC-family proteins mediated transport TAS Reactome





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