Gene description for BAIAP3
Gene name BAI1-associated protein 3
Gene symbol BAIAP3
Other names/aliases BAP3
Species Homo sapiens
 Database cross references - BAIAP3
ExoCarta ExoCarta_8938
Vesiclepedia VP_8938
Entrez Gene 8938
HGNC 948
MIM 604009
UniProt O94812  
 BAIAP3 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for BAIAP3
Molecular Function
    SNARE binding GO:0000149 IBA
    SNARE binding GO:0000149 IDA
    SNARE binding GO:0000149 IPI
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
    phospholipid binding GO:0005543 IDA
    syntaxin binding GO:0019905 IPI
Biological Process
    positive regulation of neurotransmitter secretion GO:0001956 IBA
    positive regulation of neurotransmitter secretion GO:0001956 IMP
    exocytosis GO:0006887 IEA
    G protein-coupled receptor signaling pathway GO:0007186 IPI
    regulation of synaptic transmission, GABAergic GO:0032228 ISS
    positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IMP
    retrograde transport, endosome to Golgi GO:0042147 IDA
    regulation of behavior GO:0050795 IEA
    regulation of dense core granule exocytosis GO:1905413 IBA
    regulation of dense core granule exocytosis GO:1905413 IDA
    dense core granule maturation GO:1990502 IMP
Subcellular Localization
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    dense core granule GO:0031045 IDA
    early endosome membrane GO:0031901 IDA
    late endosome membrane GO:0031902 IBA
    late endosome membrane GO:0031902 IDA
    trans-Golgi network membrane GO:0032588 IBA
    trans-Golgi network membrane GO:0032588 IDA
    recycling endosome membrane GO:0055038 IBA
    recycling endosome membrane GO:0055038 IDA
    presynapse GO:0098793 IEA
    GABA-ergic synapse GO:0098982 IEA
    secretory vesicle GO:0099503 IBA
 Experiment description of studies that identified BAIAP3 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for BAIAP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APEX1 328
Affinity Capture-RNA Homo sapiens
2 BAI1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which BAIAP3 is involved
No pathways found





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