Gene description for HPS4
Gene name Hermansky-Pudlak syndrome 4
Gene symbol HPS4
Other names/aliases LE
Species Homo sapiens
 Database cross references - HPS4
ExoCarta ExoCarta_89781
Entrez Gene 89781
HGNC 15844
MIM 606682
UniProt Q9NQG7  
 HPS4 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for HPS4
Molecular Function
    protein binding GO:0005515 IPI
    protein dimerization activity GO:0046983 IPI
    protein homodimerization activity GO:0042803 IPI
Biological Process
    blood coagulation GO:0007596 IEA
    positive regulation of eye pigmentation GO:0048075 TAS
    protein stabilization GO:0050821 IPI
    melanocyte differentiation GO:0030318 IEA
    hemostasis GO:0007599 TAS
    lysosome organization GO:0007040 IDA
    positive regulation of protein targeting to mitochondrion GO:1903955 IMP
    protein targeting GO:0006605 IDA
Subcellular Localization
    melanosome GO:0042470 IDA
    cytoplasm GO:0005737 IDA
    platelet dense granule GO:0042827 IDA
    BLOC-3 complex GO:0031085 IPI
    lysosome GO:0005764 IDA
    membrane GO:0016020 IDA
 Experiment description of studies that identified HPS4 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for HPS4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HPS4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here