Gene description for HPS4
Gene name	Hermansky-Pudlak syndrome 4
Gene symbol	HPS4
Other names/aliases	LE
Species	Homo sapiens
Database cross references - HPS4
ExoCarta	ExoCarta_89781
Vesiclepedia	VP_89781
Entrez Gene	89781
HGNC	15844
MIM	606682
UniProt	Q9NQG7
HPS4 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for HPS4

Molecular Function     guanyl-nucleotide exchange factor activity GO:0005085 IBA     guanyl-nucleotide exchange factor activity GO:0005085 IDA     protein binding GO:0005515 IPI     small GTPase binding GO:0031267 IBA     small GTPase binding GO:0031267 IPI     protein homodimerization activity GO:0042803 IPI     protein dimerization activity GO:0046983 IPI Biological Process     protein targeting GO:0006605 IBA     protein targeting GO:0006605 IDA     lysosome organization GO:0007040 IDA     blood coagulation GO:0007596 IEA     hemostasis GO:0007599 TAS     vesicle-mediated transport GO:0016192 IEA     melanocyte differentiation GO:0030318 IEA     intracellular transport GO:0046907 NAS     positive regulation of eye pigmentation GO:0048075 TAS     protein stabilization GO:0050821 IPI     platelet dense granule organization GO:0060155 NAS     melanosome assembly GO:1903232 IBA     melanosome assembly GO:1903232 IDA     melanosome assembly GO:1903232 NAS     positive regulation of protein targeting to mitochondrion GO:1903955 HMP Subcellular Localization     cytoplasm GO:0005737 IDA     lysosome GO:0005764 IDA     lysosomal membrane GO:0005765 IBA     cytosol GO:0005829 TAS     membrane GO:0016020 IDA     BLOC-3 complex GO:0031085 IBA     BLOC-3 complex GO:0031085 IPI     cytoplasmic vesicle GO:0031410 IBA     melanosome GO:0042470 IDA     platelet dense granule GO:0042827 IDA