Gene description for Picalm
Gene name	phosphatidylinositol binding clathrin assembly protein
Gene symbol	Picalm
Other names/aliases	Calm
Species	Rattus norvegicus
Database cross references - Picalm
ExoCarta	ExoCarta_89816
Vesiclepedia	VP_89816
Entrez Gene	89816
UniProt	O55012
Picalm identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Picalm

Molecular Function     SNARE binding GO:0000149 IBA     SNARE binding GO:0000149 IEA     SNARE binding GO:0000149 IPI     SNARE binding GO:0000149 ISO     protein binding GO:0005515 IPI     1-phosphatidylinositol binding GO:0005545 IBA     1-phosphatidylinositol binding GO:0005545 IDA     1-phosphatidylinositol binding GO:0005545 IEA     phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IBA     phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IMP     SH3 domain binding GO:0017124 IDA     clathrin binding GO:0030276 IDA     clathrin binding GO:0030276 IEA     clathrin binding GO:0030276 ISO     clathrin binding GO:0030276 ISS     small GTPase binding GO:0031267 IEA     small GTPase binding GO:0031267 ISO     clathrin heavy chain binding GO:0032050 IBA     clathrin heavy chain binding GO:0032050 IEA     clathrin heavy chain binding GO:0032050 ISO     identical protein binding GO:0042802 IPI     tau protein binding GO:0048156 IEA     tau protein binding GO:0048156 ISO     low-density lipoprotein particle receptor binding GO:0050750 IEA     low-density lipoprotein particle receptor binding GO:0050750 ISO Biological Process     intracellular iron ion homeostasis GO:0006879 IEA     intracellular iron ion homeostasis GO:0006879 ISO     endocytosis GO:0006897 ISO     receptor-mediated endocytosis GO:0006898 ISO     receptor-mediated endocytosis GO:0006898 ISS     vesicle budding from membrane GO:0006900 IEA     vesicle budding from membrane GO:0006900 ISO     axonogenesis GO:0007409 IEA     axonogenesis GO:0007409 IMP     axonogenesis GO:0007409 ISO     learning or memory GO:0007611 IEA     learning or memory GO:0007611 ISO     negative regulation of gene expression GO:0010629 IEA     negative regulation of gene expression GO:0010629 ISO     negative regulation of gene expression GO:0010629 ISS     synaptic vesicle budding from presynaptic endocytic zone membrane GO:0016185 IBA     synaptic vesicle maturation GO:0016188 IEA     synaptic vesicle maturation GO:0016188 ISO     synaptic vesicle maturation GO:0016188 ISS     vesicle-mediated transport GO:0016192 IMP     endosomal transport GO:0016197 IEA     endosomal transport GO:0016197 ISO     hemopoiesis GO:0030097 IEA     hemopoiesis GO:0030097 ISO     regulation of endocytosis GO:0030100 IMP     regulation of endocytosis GO:0030100 ISO     receptor internalization GO:0031623 IEA     receptor internalization GO:0031623 ISO     regulation of protein localization GO:0032880 ISO     vesicle cargo loading GO:0035459 IEA     vesicle cargo loading GO:0035459 ISO     vesicle cargo loading GO:0035459 ISS     positive regulation of DNA-templated transcription GO:0045893 IEA     positive regulation of DNA-templated transcription GO:0045893 ISO     positive regulation of Ras protein signal transduction GO:0046579 IEA     positive regulation of Ras protein signal transduction GO:0046579 ISO     negative regulation of receptor-mediated endocytosis GO:0048261 IEA     negative regulation of receptor-mediated endocytosis GO:0048261 ISO     clathrin coat assembly GO:0048268 IDA     clathrin coat assembly GO:0048268 IEA     clathrin coat assembly GO:0048268 ISO     synaptic vesicle endocytosis GO:0048488 IDA     synaptic vesicle endocytosis GO:0048488 IMP     dendrite morphogenesis GO:0048813 IEA     dendrite morphogenesis GO:0048813 IMP     dendrite morphogenesis GO:0048813 ISO     positive regulation of axonogenesis GO:0050772 IMP     regulation of protein transport GO:0051223 IMP     multicellular organismal-level iron ion homeostasis GO:0060586 IEA     multicellular organismal-level iron ion homeostasis GO:0060586 ISO     multicellular organismal-level iron ion homeostasis GO:0060586 ISS     clathrin-dependent endocytosis GO:0072583 IBA     clathrin-dependent endocytosis GO:0072583 IEA     clathrin-dependent endocytosis GO:0072583 ISO     clathrin-dependent endocytosis GO:0072583 ISS     regulation of vesicle size GO:0097494 IEA     regulation of vesicle size GO:0097494 ISO     membrane bending GO:0097753 IEA     membrane bending GO:0097753 ISO     amyloid-beta clearance by transcytosis GO:0150093 IEA     amyloid-beta clearance by transcytosis GO:0150093 ISO     regulation of synaptic vesicle endocytosis GO:1900242 IMP     positive regulation of synaptic vesicle endocytosis GO:1900244 IMP     regulation of amyloid-beta formation GO:1902003 ISO     positive regulation of amyloid-beta formation GO:1902004 IEA     positive regulation of amyloid-beta formation GO:1902004 ISO     positive regulation of amyloid-beta formation GO:1902004 ISS     regulation of synaptic vesicle transport GO:1902803 IMP     regulation of amyloid precursor protein catabolic process GO:1902991 ISO     regulation of amyloid precursor protein catabolic process GO:1902991 ISS     positive regulation of amyloid precursor protein catabolic process GO:1902993 ISO     positive regulation of amyloid precursor protein catabolic process GO:1902993 ISS     negative regulation of protein localization to plasma membrane GO:1903077 IEA     negative regulation of protein localization to plasma membrane GO:1903077 ISO     positive regulation of dendrite extension GO:1903861 IMP     negative regulation of protein localization to cell surface GO:2000009 IEA     negative regulation of protein localization to cell surface GO:2000009 ISO     regulation of terminal button organization GO:2000331 IMP     positive regulation of synaptic vesicle clustering GO:2000809 IMP Subcellular Localization     nucleus GO:0005634 IEA     nucleus GO:0005634 ISO     endosome GO:0005768 IDA     early endosome GO:0005769 IEA     early endosome GO:0005769 ISO     Golgi apparatus GO:0005794 IEA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     clathrin-coated pit GO:0005905 IBA     clathrin-coated pit GO:0005905 ISO     clathrin-coated pit GO:0005905 ISS     synaptic vesicle GO:0008021 IBA     synaptic vesicle GO:0008021 IDA     cell surface GO:0009986 IEA     cell surface GO:0009986 ISO     postsynaptic density GO:0014069 IDA     membrane GO:0016020 IMP     clathrin coat of coated pit GO:0030132 IEA     clathrin coat of coated pit GO:0030132 ISO     clathrin-coated vesicle GO:0030136 IBA     clathrin-coated vesicle GO:0030136 IDA     clathrin-coated vesicle GO:0030136 IEA     clathrin-coated vesicle GO:0030136 ISO     vesicle GO:0031982 ISO     vesicle GO:0031982 ISS     presynaptic membrane GO:0042734 IDA     neuronal cell body GO:0043025 IDA     neuronal cell body GO:0043025 IEA     neuronal cell body GO:0043025 ISO     neuronal cell body GO:0043025 ISS     intracellular membrane-bounded organelle GO:0043231 ISO     postsynaptic membrane GO:0045211 IDA     perinuclear region of cytoplasm GO:0048471 IEA     perinuclear region of cytoplasm GO:0048471 ISO     endosome to plasma membrane transport vesicle GO:0070381 IEA     endosome to plasma membrane transport vesicle GO:0070381 ISO     neurofibrillary tangle GO:0097418 IEA     neurofibrillary tangle GO:0097418 ISO     neurofibrillary tangle GO:0097418 ISS     Schaffer collateral - CA1 synapse GO:0098685 IDA     parallel fiber to Purkinje cell synapse GO:0098688 IDA     postsynapse GO:0098794 IDA     postsynaptic endocytic zone GO:0098843 IDA     postsynaptic endocytic zone GO:0098843 IMP     extrinsic component of presynaptic endocytic zone membrane GO:0098894 IBA     extrinsic component of presynaptic endocytic zone membrane GO:0098894 IDA