Gene description for ZNF486
Gene name zinc finger protein 486
Gene symbol ZNF486
Other names/aliases KRBO2
Species Homo sapiens
 Database cross references - ZNF486
ExoCarta ExoCarta_90649
Vesiclepedia VP_90649
Entrez Gene 90649
HGNC 20807
UniProt Q96H40  
 ZNF486 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ZNF486
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    regulation of DNA-templated transcription GO:0006355 IBA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified ZNF486 in sEVs
1
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ZNF486
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 LDLR 3949
Negative Genetic Homo sapiens
3 TRIM28 10155
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZNF486 is involved
PathwayEvidenceSource
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
RNA Polymerase II Transcription TAS Reactome





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