Gene description for PCSK7
Gene name proprotein convertase subtilisin/kexin type 7
Gene symbol PCSK7
Other names/aliases LPC
PC7
PC8
SPC7
Species Homo sapiens
 Database cross references - PCSK7
ExoCarta ExoCarta_9159
Vesiclepedia VP_9159
Entrez Gene 9159
HGNC 8748
MIM 604872
UniProt Q16549  
 PCSK7 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PCSK7
Molecular Function
    serine-type endopeptidase activity GO:0004252 IBA
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 IDA
Biological Process
    protein processing GO:0016485 IBA
    protein processing GO:0016485 IDA
    peptide hormone processing GO:0016486 NAS
Subcellular Localization
    Golgi membrane GO:0000139 IBA
    Golgi membrane GO:0000139 IDA
    trans-Golgi network GO:0005802 IBA
 Experiment description of studies that identified PCSK7 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PCSK7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIM54  
Two-hybrid Homo sapiens
2 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
View the network image/svg+xml
 Pathways in which PCSK7 is involved
No pathways found





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