Gene description for Bag6
Gene name BCL2-associated athanogene 6
Gene symbol Bag6
Other names/aliases Bat3
Species Rattus norvegicus
 Database cross references - Bag6
ExoCarta ExoCarta_94342
Entrez Gene 94342
UniProt Q6MG49  
 Bag6 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Bag6
Molecular Function
    Hsp70 protein binding GO:0030544 ISO
    polyubiquitin binding GO:0031593 ISS
    ribosome binding GO:0043022 ISS
    ubiquitin protein ligase binding GO:0031625 ISO
    proteasome binding GO:0070628 ISS
Biological Process
    brain development GO:0007420 ISS
    regulation of apoptotic process GO:0042981 ISO
    transport GO:0006810 IEA
    regulation of cell proliferation GO:0042127 IEP
    negative regulation of proteolysis GO:0045861 ISS
    synaptonemal complex assembly GO:0007130 ISS
    immune system process GO:0002376 IEA
    internal peptidyl-lysine acetylation GO:0018393 ISS
    kidney development GO:0001822 ISS
    cell differentiation GO:0030154 IEA
    tail-anchored membrane protein insertion into ER membrane GO:0071816 ISS
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 ISS
    protein stabilization GO:0050821 ISS
    spermatogenesis GO:0007283 ISS
    lung development GO:0030324 ISS
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 ISS
    ubiquitin-dependent protein catabolic process GO:0006511 ISS
    negative regulation of apoptotic process GO:0043066 ISO
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 ISS
    chromatin modification GO:0016568 IEA
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 ISO
    BAT3 complex GO:0071818 ISS
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    intracellular GO:0005622 ISO
    nucleus GO:0005634 ISS
    cytosol GO:0005829 ISS
 Experiment description of studies that identified Bag6 in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Bag6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Bag6 is involved
No pathways found





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