Gene description for CHST2
Gene name carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
Gene symbol CHST2
Other names/aliases C6ST
GST-2
GST2
Gn6ST-1
HEL-S-75
glcNAc6ST-1
Species Homo sapiens
 Database cross references - CHST2
ExoCarta ExoCarta_9435
Entrez Gene 9435
HGNC 1970
MIM 603798
UniProt Q9Y4C5  
 CHST2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for CHST2
Molecular Function
    sulfotransferase activity GO:0008146 TAS
    N-acetylglucosamine 6-O-sulfotransferase activity GO:0001517 IDA
Biological Process
    multicellular organismal development GO:0007275 TAS
    carbohydrate metabolic process GO:0005975 TAS
    keratan sulfate metabolic process GO:0042339 TAS
    small molecule metabolic process GO:0044281 TAS
    inflammatory response GO:0006954 IEA
    sulfur compound metabolic process GO:0006790 IDA
    glycosaminoglycan metabolic process GO:0030203 TAS
    keratan sulfate biosynthetic process GO:0018146 TAS
    N-acetylglucosamine metabolic process GO:0006044 IDA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    trans-Golgi network GO:0005802 IDA
    intrinsic component of Golgi membrane GO:0031228 NAS
    Golgi membrane GO:0000139 TAS
 Experiment description of studies that identified CHST2 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for CHST2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CHST2 is involved
PathwayEvidenceSource
Keratan sulfate biosynthesis TAS Reactome





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