Gene description for ADAMTS3
Gene name ADAM metallopeptidase with thrombospondin type 1 motif, 3
Gene symbol ADAMTS3
Other names/aliases ADAMTS-4
Species Homo sapiens
 Database cross references - ADAMTS3
ExoCarta ExoCarta_9508
Entrez Gene 9508
HGNC 219
MIM 605011
UniProt O15072  
 ADAMTS3 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for ADAMTS3
Molecular Function
    endopeptidase activity GO:0004175 IDA
    metalloendopeptidase activity GO:0004222 NAS
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 NAS
    heparin binding GO:0008201 IEA
Biological Process
    collagen catabolic process GO:0030574 NAS
    positive regulation of vascular endothelial growth factor signaling pathway GO:1900748 IDA
    protein processing GO:0016485 IDA
    vascular endothelial growth factor production GO:0010573 IDA
    collagen biosynthetic process GO:0032964 IDA
    collagen fibril organization GO:0030199 NAS
    extracellular fibril organization GO:0043206 IC
    extracellular matrix organization GO:0030198 TAS
Subcellular Localization
    proteinaceous extracellular matrix GO:0005578 NAS
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IDA
    extracellular matrix GO:0031012 TAS
 Experiment description of studies that identified ADAMTS3 in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for ADAMTS3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ADAMTS3 is involved
PathwayEvidenceSource
Collagen biosynthesis and modifying enzymes TAS Reactome
O-glycosylation of TSR domain-containing proteins TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here