Gene description for TRANK1
Gene name tetratricopeptide repeat and ankyrin repeat containing 1
Gene symbol TRANK1
Other names/aliases LBA1
Species Homo sapiens
 Database cross references - TRANK1
ExoCarta ExoCarta_9881
Entrez Gene 9881
HGNC 29011
UniProt O15050  
 TRANK1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TRANK1
Molecular Function
    hydrolase activity GO:0016787 IEA
    ATP binding GO:0005524 IEA
Biological Process
    metabolic process GO:0008152 IEA
 Experiment description of studies that identified TRANK1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TRANK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TRANK1 is involved
No pathways found





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