Gene description for FGF19
Gene name fibroblast growth factor 19
Gene symbol FGF19
Other names/aliases -
Species Homo sapiens
 Database cross references - FGF19
ExoCarta ExoCarta_9965
Vesiclepedia VP_9965
Entrez Gene 9965
HGNC 3675
MIM 603891
UniProt O95750  
 FGF19 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for FGF19
Molecular Function
    fibroblast growth factor receptor binding GO:0005104 IBA
    fibroblast growth factor receptor binding GO:0005104 IPI
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IBA
Biological Process
    neural crest cell migration GO:0001755 IEA
    positive regulation of protein phosphorylation GO:0001934 IDA
    nervous system development GO:0007399 TAS
    heart development GO:0007507 IEA
    positive regulation of cell population proliferation GO:0008284 IBA
    positive regulation of cell population proliferation GO:0008284 IGI
    fibroblast growth factor receptor signaling pathway GO:0008543 IBA
    fibroblast growth factor receptor signaling pathway GO:0008543 IGI
    fibroblast growth factor receptor signaling pathway GO:0008543 IPI
    response to bacterium GO:0009617 IEA
    negative regulation of gene expression GO:0010629 IDA
    response to organic cyclic compound GO:0014070 IEA
    bile acid and bile salt transport GO:0015721 IEA
    neurogenesis GO:0022008 IBA
    regulation of cell migration GO:0030334 IBA
    positive regulation of MAPK cascade GO:0043410 IBA
    response to ethanol GO:0045471 IEA
    positive regulation of D-glucose import GO:0046326 IDA
    positive regulation of JNK cascade GO:0046330 IDA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    negative regulation of bile acid biosynthetic process GO:0070858 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified FGF19 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for FGF19
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FGFR4 2264
Reconstituted Complex Homo sapiens
2 NPTX1  
Affinity Capture-MS Homo sapiens
3 UBR3  
Affinity Capture-MS Homo sapiens
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