Experiment description of studies that identified NACC1 in sEVs

1 Experiment ID 235 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|Alix|HSC70|GAPDH Enriched markers ✔ HSP90B1 Negative markers ✔ qNano Particle analysis Identified molecule mRNA Identification method RNA Sequencing PubMed ID 26054723     Organism Homo sapiens Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N" Journal name Carcinogenesis Publication year 2015 Sample Hepatocellular carcinoma cells Sample name HKCI-8 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.13-1.19 g/mL Molecules identified in the study Protein RNA Methods used in the study Western blotting Mass spectrometry RT-PCR RNA Sequencing

Protein-protein interactions for NACC1

Protein Interactor ExoCarta ID Identification method PubMed Species 1 ZBTB14   Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens 2 SOX6   Proximity Label-MS Homo sapiens 3 SENP2 59343 Biochemical Activity Homo sapiens 4 HDAC4   Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens Two-hybrid Homo sapiens Reconstituted Complex Homo sapiens 5 KPNA3 3839 Affinity Capture-Western Homo sapiens 6 DEFB136   Affinity Capture-MS Homo sapiens 7 FOXP3   Affinity Capture-MS Homo sapiens 8 STRN3 29966 Proximity Label-MS Homo sapiens 9 RBPJ 3516 Affinity Capture-MS Homo sapiens 10 CBX3 11335 Proximity Label-MS Homo sapiens 11 XPO1 7514 Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens 12 ITLN1 55600 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 13 POLR2L 5441 Two-hybrid Homo sapiens 14 TARDBP 23435 Reconstituted Complex Homo sapiens Reconstituted Complex Homo sapiens 15 MATN4 8785 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 16 EHHADH 1962 Two-hybrid Homo sapiens 17 MRPL43 84545 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 18 FOXA1   Affinity Capture-MS Homo sapiens 19 CUL3 8452 Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens 20 NR3C1 2908 Proximity Label-MS Homo sapiens 21 TBK1 29110 Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens 22 SP7   Proximity Label-MS Homo sapiens 23 PRPF3   Two-hybrid Homo sapiens 24 PARK2   Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens 25 NACC1 112939 Affinity Capture-Western Homo sapiens Co-crystal Structure Homo sapiens Affinity Capture-Western Homo sapiens Co-crystal Structure Homo sapiens 26 C8orf33 65265 Two-hybrid Homo sapiens 27 PSMD7 5713 Affinity Capture-Western Homo sapiens 28 ESR1   Affinity Capture-MS Homo sapiens 29 DUSP13   Affinity Capture-MS Homo sapiens 30 PRKCI 5584 Two-hybrid Homo sapiens 31 FOXJ2   Affinity Capture-MS Homo sapiens 32 KPNA4 3840 Affinity Capture-Western Homo sapiens 33 MAP3K5 4217 Affinity Capture-MS Homo sapiens 34 NUP50 10762 Proximity Label-MS Homo sapiens 35 UBE2I 7329 Biochemical Activity Homo sapiens Affinity Capture-Western Homo sapiens 36 C12orf49   Positive Genetic Homo sapiens 37 HDAC3 8841 Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens Reconstituted Complex Homo sapiens 38 CCNB1 891 Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 39 ENC1   Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens 40 RPA3 6119 Proximity Label-MS Homo sapiens 41 LSM3 27258 Two-hybrid Homo sapiens 42 UBTFL1   Two-hybrid Homo sapiens 43 ZBTB9   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 44 NACC2   Affinity Capture-MS Homo sapiens 45 SENP1   Biochemical Activity Homo sapiens 46 ZBTB6   Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens 47 ZNF512B   Two-hybrid Homo sapiens 48 CDC45   Affinity Capture-MS Homo sapiens 49 BCL6   Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens 50 PML 5371 Reconstituted Complex Homo sapiens 51 PRPF18   Two-hybrid Homo sapiens 52 BRPF3   Affinity Capture-MS Homo sapiens 53 LGALS8 3964 Two-hybrid Homo sapiens 54 ZBTB42   Affinity Capture-MS Homo sapiens 55 NDUFC2 4718 Affinity Capture-MS Homo sapiens 56 SRP14 6727 Affinity Capture-MS Homo sapiens 57 CEBPA   Proximity Label-MS Homo sapiens 58 MAVS 57506 Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens 59 COIL   Proximity Label-MS Homo sapiens 60 CUL4A 8451 Affinity Capture-Western Homo sapiens 61 KLHL2 11275 Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens 62 GREM2 64388 Affinity Capture-MS Homo sapiens 63 FOXA2   Affinity Capture-MS Homo sapiens 64 BCOR   Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens View the network

Pathways in which NACC1 is involved

No pathways found