Gene description for LACTB
Gene name lactamase, beta
Gene symbol LACTB
Other names/aliases G24
MRPL56
Species Homo sapiens
 Database cross references - LACTB
ExoCarta ExoCarta_114294
Vesiclepedia VP_114294
Entrez Gene 114294
HGNC 16468
MIM 608440
UniProt P83111  
 LACTB identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for LACTB
Molecular Function
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 IBA
    peptidase activity GO:0008233 IDA
    identical protein binding GO:0042802 IEA
Biological Process
    proteolysis GO:0006508 IBA
    proteolysis GO:0006508 IDA
    lipid metabolic process GO:0006629 IEA
    regulation of lipid metabolic process GO:0019216 IBA
    regulation of lipid metabolic process GO:0019216 IDA
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified LACTB in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LACTB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTPRF 5792
Two-hybrid Homo sapiens
2 ATP6V1B2 526
Co-fractionation Homo sapiens
3 RIOK1 83732
Affinity Capture-MS Homo sapiens
4 POR 5447
Co-fractionation Homo sapiens
5 SPRTN  
Affinity Capture-MS Homo sapiens
6 PAXIP1  
Two-hybrid Homo sapiens
7 NDUFS1 4719
Co-fractionation Homo sapiens
8 WWP1 11059
Affinity Capture-MS Homo sapiens
9 COPRS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 NMNAT1  
Affinity Capture-MS Homo sapiens
11 KIF20A 10112
Affinity Capture-MS Homo sapiens
12 UBC 7316
Reconstituted Complex Homo sapiens
13 CALM1 801
Reconstituted Complex Homo sapiens
14 PDHB 5162
Co-fractionation Homo sapiens
15 UBXN2A  
Affinity Capture-MS Homo sapiens
16 NDUFS2 4720
Co-fractionation Homo sapiens
17 APP 351
Co-fractionation Homo sapiens
18 LRPPRC 10128
Co-fractionation Homo sapiens
19 NDUFS3 4722
Co-fractionation Homo sapiens
20 PRDX3 10935
Affinity Capture-MS Homo sapiens
21 KIF23 9493
Affinity Capture-MS Homo sapiens
22 DNAJC11 55735
Co-fractionation Homo sapiens
23 CKMT1A 548596
Affinity Capture-MS Homo sapiens
24 Isy1 57905
Affinity Capture-MS Mus musculus
25 PCBD1 5092
Affinity Capture-MS Homo sapiens
26 PRC1 9055
Affinity Capture-MS Homo sapiens
27 ARMCX3 51566
Co-fractionation Homo sapiens
28 SURF1  
Proximity Label-MS Homo sapiens
29 LACTB 114294
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 NDUFV1 4723
Co-fractionation Homo sapiens
31 NSFL1C 55968
Affinity Capture-MS Homo sapiens
32 SNX27 81609
Affinity Capture-MS Homo sapiens
33 TSN 7247
Affinity Capture-MS Homo sapiens
34 CKMT2  
Affinity Capture-MS Homo sapiens
35 KCTD6  
Affinity Capture-MS Homo sapiens
36 KIF14 9928
Affinity Capture-MS Homo sapiens
37 SFTPC  
Affinity Capture-MS Homo sapiens
38 CCDC102A 92922
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 IMPDH1 3614
Affinity Capture-MS Homo sapiens
40 APOO 79135
Proximity Label-MS Homo sapiens
41 CAMK2A 815
Affinity Capture-MS Homo sapiens
42 DLD 1738
Co-fractionation Homo sapiens
43 P4HA1 5033
Co-fractionation Homo sapiens
44 QPRT 23475
Affinity Capture-MS Homo sapiens
45 TUFM 7284
Co-fractionation Homo sapiens
46 DIABLO 56616
Proximity Label-MS Homo sapiens
47 VCP 7415
Co-fractionation Homo sapiens
48 OGT 8473
Reconstituted Complex Homo sapiens
49 CRP  
Affinity Capture-MS Homo sapiens
50 POLDIP2 26073
Affinity Capture-MS Homo sapiens
51 CYC1 1537
Co-fractionation Homo sapiens
52 UQCRC1 7384
Co-fractionation Homo sapiens
53 COX4I1 1327
Proximity Label-MS Homo sapiens
54 ANLN 54443
Affinity Capture-MS Homo sapiens
55 ECH1 1891
Affinity Capture-MS Homo sapiens
56 SLC25A24 29957
Co-fractionation Homo sapiens
57 SLC25A12 8604
Proximity Label-MS Homo sapiens
58 MINOS1  
Co-fractionation Homo sapiens
59 AIFM1 9131
Proximity Label-MS Homo sapiens
60 CANX 821
Co-fractionation Homo sapiens
61 PITRM1 10531
Affinity Capture-MS Homo sapiens
62 LRRC59 55379
Co-fractionation Homo sapiens
63 ECT2 1894
Affinity Capture-MS Homo sapiens
64 UQCRC2 7385
Co-fractionation Homo sapiens
65 HMOX2 3163
Co-fractionation Homo sapiens
66 CTNNB1 1499
Co-fractionation Homo sapiens
67 MARCH8  
Affinity Capture-MS Homo sapiens
68 NIPSNAP3A  
Affinity Capture-MS Homo sapiens
69 Wash  
Affinity Capture-MS Mus musculus
70 CORO1C 23603
Co-fractionation Homo sapiens
71 OCIAD1 54940
Proximity Label-MS Homo sapiens
72 KCNE3  
Affinity Capture-MS Homo sapiens
73 MYC  
Affinity Capture-MS Homo sapiens
74 COX6C 1345
Co-fractionation Homo sapiens
75 EMC2 9694
Co-fractionation Homo sapiens
76 ASPH 444
Co-fractionation Homo sapiens
77 AUH 549
Co-fractionation Homo sapiens
78 RCN2 5955
Co-fractionation Homo sapiens
79 DDRGK1 65992
Affinity Capture-MS Homo sapiens
80 NDUFV2 4729
Co-fractionation Homo sapiens
81 GNPDA1 10007
Affinity Capture-MS Homo sapiens
82 UBXN2B  
Affinity Capture-MS Homo sapiens
83 IMMT 10989
Co-fractionation Homo sapiens
84 FTL 2512
Affinity Capture-MS Homo sapiens
85 DNAJC4  
Proximity Label-MS Homo sapiens
86 PHB2 11331
Proximity Label-MS Homo sapiens
87 ZNFX1 57169
Affinity Capture-MS Homo sapiens
88 HSPB2  
Affinity Capture-MS Homo sapiens
89 CDA 978
Affinity Capture-MS Homo sapiens
90 LONP1 9361
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
91 BCKDHA 593
Co-fractionation Homo sapiens
92 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
93 COX8A  
Co-fractionation Homo sapiens
94 FOXN1  
Affinity Capture-MS Homo sapiens
95 NIPSNAP3B 55335
Affinity Capture-MS Homo sapiens
96 SFXN1 94081
Proximity Label-MS Homo sapiens
97 NNT 23530
Co-fractionation Homo sapiens
98 NME4 4833
Affinity Capture-MS Homo sapiens
99 GLUL 2752
Affinity Capture-MS Homo sapiens
100 IBTK 25998
Affinity Capture-MS Homo sapiens
101 C19orf52  
Proximity Label-MS Homo sapiens
102 SLC25A51  
Proximity Label-MS Homo sapiens
103 CIT 11113
Affinity Capture-MS Homo sapiens
104 C1QBP 708
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
105 KCTD17 79734
Affinity Capture-MS Homo sapiens
106 TFAM 7019
Co-fractionation Homo sapiens
107 CUL4A 8451
Affinity Capture-MS Homo sapiens
108 NPTX2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LACTB is involved
No pathways found





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