Gene description for Vdac3
Gene name voltage-dependent anion channel 3
Gene symbol Vdac3
Other names/aliases -
Species Mus musculus
 Database cross references - Vdac3
ExoCarta ExoCarta_22335
Vesiclepedia VP_22335
Entrez Gene 22335
UniProt Q60931  
 Vdac3 identified in sEVs derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Vdac3
Molecular Function
    nucleotide binding GO:0000166 IEA
    protein binding GO:0005515 IPI
    voltage-gated monoatomic anion channel activity GO:0008308 IBA
    voltage-gated monoatomic anion channel activity GO:0008308 IEA
    porin activity GO:0015288 IEA
Biological Process
    behavioral fear response GO:0001662 IMP
    chemical synaptic transmission GO:0007268 IMP
    neuron-neuron synaptic transmission GO:0007270 IMP
    spermatogenesis GO:0007283 IMP
    learning GO:0007612 IMP
    monoatomic anion transmembrane transport GO:0098656 IEA
    sperm mitochondrial sheath assembly GO:0120317 IMP
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 ISO
    mitochondrial outer membrane GO:0005741 IBA
    mitochondrial outer membrane GO:0005741 IEA
    mitochondrial inner membrane GO:0005743 HDA
    synaptic vesicle GO:0008021 ISO
    membrane GO:0016020 ISO
    synapse GO:0045202 IEA
    pore complex GO:0046930 IEA
 Experiment description of studies that identified Vdac3 in sEVs
1
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Vdac3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sdha 66945
Co-fractionation Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Slc26a8  
Co-fractionation Mus musculus
4 SNCA 6622
Affinity Capture-MS Homo sapiens
5 Atxn1  
Proximity Label-MS Mus musculus
Affinity Capture-MS Mus musculus
6 Atp5a1 11946
Co-fractionation Mus musculus
7 Eed  
Affinity Capture-MS Mus musculus
8 Csrp3  
Co-fractionation Mus musculus
9 Rps5 20103
Co-fractionation Mus musculus
10 Mapt  
Affinity Capture-MS Mus musculus
11 Slc25a4 11739
Co-fractionation Mus musculus
12 Ndufv2  
Co-fractionation Mus musculus
13 Ndufs4  
Co-fractionation Mus musculus
14 Fancd2  
Affinity Capture-MS Mus musculus
15 Vdac3 22335
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
16 Tomm70a  
Co-fractionation Mus musculus
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