Gene description for Cops4
Gene name COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)
Gene symbol Cops4
Other names/aliases AW208976
D5Ertd774e
Species Mus musculus
 Database cross references - Cops4
ExoCarta ExoCarta_26891
Vesiclepedia VP_26891
Entrez Gene 26891
UniProt O88544  
 Cops4 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cops4
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    protein deneddylation GO:0000338 ISO
    protein deneddylation GO:0000338 ISS
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    synaptic vesicle GO:0008021 IEA
    synaptic vesicle GO:0008021 ISO
    COP9 signalosome GO:0008180 IBA
    COP9 signalosome GO:0008180 IDA
    COP9 signalosome GO:0008180 ISO
    nuclear speck GO:0016607 IEA
    nuclear speck GO:0016607 ISO
    cell junction GO:0030054 ISO
 Experiment description of studies that identified Cops4 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cops4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Stip1 20867
Co-fractionation Mus musculus
2 Skp1a 21402
Co-fractionation Mus musculus
3 Cops5 26754
Affinity Capture-Western Mus musculus
4 Ubc  
Reconstituted Complex Mus musculus
5 Atxn1  
Affinity Capture-MS Mus musculus
6 CUL1 8454
Affinity Capture-MS Homo sapiens
7 MTNR1A  
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
8 Nudt16l1  
Co-fractionation Mus musculus
9 Socs3  
Affinity Capture-Western Mus musculus
10 Cops2 12848
Affinity Capture-Western Mus musculus
11 Rbx1  
Co-fractionation Mus musculus
12 Snapin  
Co-fractionation Mus musculus
13 Chaf1a  
Affinity Capture-MS Mus musculus
14 Gps1 209318
Affinity Capture-Western Mus musculus
15 Cops6 26893
Two-hybrid Mus musculus
View the network image/svg+xml



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