Gene description for MCM10
Gene name minichromosome maintenance complex component 10
Gene symbol MCM10
Other names/aliases CNA43
DNA43
PRO2249
Species Homo sapiens
 Database cross references - MCM10
ExoCarta ExoCarta_55388
Vesiclepedia VP_55388
Entrez Gene 55388
HGNC 18043
MIM 609357
UniProt Q7L590  
 MCM10 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for MCM10
Molecular Function
    DNA replication origin binding GO:0003688 IBA
    single-stranded DNA binding GO:0003697 IBA
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IEA
    identical protein binding GO:0042802 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    DNA replication initiation GO:0006270 IBA
    DNA replication initiation GO:0006270 IMP
    DNA damage response GO:0006974 IMP
    cell population proliferation GO:0008283 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IMP
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    nuclear replication fork GO:0043596 IBA
 Experiment description of studies that identified MCM10 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for MCM10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNL2 29889
Affinity Capture-MS Homo sapiens
2 POLR2G 5436
Affinity Capture-MS Homo sapiens
3 MCM3 4172
Reconstituted Complex Homo sapiens
4 ORC2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 TNIP1 10318
Two-hybrid Homo sapiens
6 CACNG5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ORC4  
Reconstituted Complex Homo sapiens
8 CCDC85B  
Two-hybrid Homo sapiens
9 YWHAE 7531
Reconstituted Complex Homo sapiens
10 VPRBP 9730
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 MCM7 4176
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ANAPC15  
Affinity Capture-MS Homo sapiens
13 NOP56 10528
Proximity Label-MS Homo sapiens
14 MAP4 4134
Affinity Capture-MS Homo sapiens
15 RPL15 6138
Affinity Capture-MS Homo sapiens
16 HOOK2  
Two-hybrid Homo sapiens
17 FAXC  
Affinity Capture-MS Homo sapiens
18 APP 351
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
19 Mcm6 17219
Two-hybrid Mus musculus
20 CENPA  
Proximity Label-MS Homo sapiens
21 HIST2H2AA3 8337
Affinity Capture-MS Homo sapiens
22 HIST1H2BD 3017
Affinity Capture-MS Homo sapiens
23 TEX264 51368
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CEP70  
Two-hybrid Homo sapiens
25 MCM2 4171
Reconstituted Complex Homo sapiens
26 CCDC14  
Affinity Capture-MS Homo sapiens
27 KLHL40  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 CALCOCO2  
Two-hybrid Homo sapiens
29 SLC31A1 1317
Affinity Capture-MS Homo sapiens
30 MCM6 4175
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 Fgfr1op  
Affinity Capture-MS Mus musculus
32 RAB35 11021
Proximity Label-MS Homo sapiens
33 TNFRSF1B  
Affinity Capture-MS Homo sapiens
34 USP37  
Proximity Label-MS Homo sapiens
35 NINL  
Two-hybrid Homo sapiens
36 Mcm2 17216
Two-hybrid Mus musculus
37 CAV3 859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 S100A2 6273
Affinity Capture-MS Homo sapiens
39 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
40 MCC 4163
Affinity Capture-MS Homo sapiens
41 DPPA2  
Two-hybrid Homo sapiens
42 RBX1 9978
Affinity Capture-Western Homo sapiens
43 CDKN1A  
Reconstituted Complex Homo sapiens
44 SUPT5H 6829
Affinity Capture-MS Homo sapiens
45 EIF2B5 8893
Affinity Capture-MS Homo sapiens
46 GOLGA2 2801
Two-hybrid Homo sapiens
47 OFD1 8481
Affinity Capture-MS Homo sapiens
48 RELL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 AKR7L 246181
Affinity Capture-MS Homo sapiens
50 NTRK1 4914
Affinity Capture-MS Homo sapiens
51 RPL31 6160
Proximity Label-MS Homo sapiens
52 PNMA2  
Affinity Capture-MS Homo sapiens
53 APBA1  
Affinity Capture-MS Homo sapiens
54 HECTD1 25831
Affinity Capture-MS Homo sapiens
55 CEP72  
Two-hybrid Homo sapiens
56 TMEM171  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 ZBTB43  
Two-hybrid Homo sapiens
58 PIPSL 266971
Affinity Capture-MS Homo sapiens
59 DISC1 27185
Affinity Capture-MS Homo sapiens
60 EMC8 10328
Affinity Capture-MS Homo sapiens
61 CKAP2  
Affinity Capture-MS Homo sapiens
62 MCM4 4173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 ATG14  
Affinity Capture-MS Homo sapiens
64 TMEM74  
Affinity Capture-MS Homo sapiens
65 NCKAP5  
Affinity Capture-MS Homo sapiens
66 MAPRE3  
Proximity Label-MS Homo sapiens
67 KCNE3  
Affinity Capture-MS Homo sapiens
68 Cep72  
Affinity Capture-MS Mus musculus
69 MICB  
Affinity Capture-MS Homo sapiens
70 MCMBP 79892
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
72 CDC45  
Reconstituted Complex Homo sapiens
73 DDB1 1642
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
74 RHOB 388
Proximity Label-MS Homo sapiens
75 PCM1 5108
Proximity Label-MS Homo sapiens
76 CDC7  
Reconstituted Complex Homo sapiens
77 CCND1 595
Reconstituted Complex Homo sapiens
78 IKZF5 64376
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 FTL 2512
Affinity Capture-MS Homo sapiens
80 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
81 ZBTB8A  
Two-hybrid Homo sapiens
82 TRIM52  
Affinity Capture-MS Homo sapiens
83 EHHADH 1962
Affinity Capture-MS Homo sapiens
84 RPAP1  
Affinity Capture-MS Homo sapiens
85 IKBKG 8517
Reconstituted Complex Homo sapiens
86 Timeless  
Affinity Capture-MS Mus musculus
87 CDC6  
Reconstituted Complex Homo sapiens
88 KRT15 3866
Two-hybrid Homo sapiens
89 FAM35A  
Proximity Label-MS Homo sapiens
90 CDK6 1021
Reconstituted Complex Homo sapiens
91 MAGEA9  
Affinity Capture-MS Homo sapiens
92 SIRT1  
Co-fractionation Homo sapiens
93 NIFK 84365
Proximity Label-MS Homo sapiens
94 CCT7 10574
Cross-Linking-MS (XL-MS) Homo sapiens
95 TRIM37  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
96 Rprd1b  
Affinity Capture-MS Mus musculus
97 CUL4A 8451
Affinity Capture-Western Homo sapiens
98 EVA1B 55194
Affinity Capture-MS Homo sapiens
99 PRAF2 11230
Affinity Capture-MS Homo sapiens
100 ORC3  
Reconstituted Complex Homo sapiens
101 TPH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 CDKN2A 1029
Reconstituted Complex Homo sapiens
103 CDC5L 988
Reconstituted Complex Homo sapiens
104 CCND3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
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