Gene description for PTPRH
Gene name protein tyrosine phosphatase, receptor type, H
Gene symbol PTPRH
Other names/aliases R-PTP-H
SAP1
Species Homo sapiens
 Database cross references - PTPRH
ExoCarta ExoCarta_5794
Vesiclepedia VP_5794
Entrez Gene 5794
HGNC 9672
MIM 602510
 PTPRH identified in sEVs derived from the following tissue/cell type
Pancreatic duct fluid 29339034    
Pancreatic duct fluid 29339034    
 Gene ontology annotations for PTPRH
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IBA
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    transmembrane receptor protein tyrosine phosphatase activity GO:0005001 TAS
    protein binding GO:0005515 IPI
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    cadherin binding GO:0045296 IPI
    histone H2AXY142 phosphatase activity GO:0140793 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    protein dephosphorylation GO:0006470 TAS
    apoptotic process GO:0006915 IEA
    signal transduction GO:0007165 IBA
    axon guidance GO:0007411 IBA
Subcellular Localization
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    apical plasma membrane GO:0016324 IEA
    nuclear speck GO:0016607 IDA
    microvillus membrane GO:0031528 IEA
 Experiment description of studies that identified PTPRH in sEVs
1
Experiment ID 622
MISEV standards
EM
Biophysical techniques
Enriched markers
GOLGA2|CYC1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 29339034    
Organism Homo sapiens
Experiment description Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer
Authors "Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G, Basturk O, Gonen M, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Lyden D, Jarnagin WR."
Journal name HPB
Publication year 2018
Sample Pancreatic duct fluid
Sample name From patients with Pancreatic ductal adenocarcinoma
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 623
MISEV standards
Biophysical techniques
Enriched markers
GOLGA2|CYC1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 29339034    
Organism Homo sapiens
Experiment description Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer
Authors "Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G, Basturk O, Gonen M, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Lyden D, Jarnagin WR."
Journal name HPB
Publication year 2018
Sample Pancreatic duct fluid
Sample name From patients with IPMN with microinvasive cancer (IPMNca)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PTPRH
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RALGAPA1 253959
Proximity Label-MS Homo sapiens
2 ERBB2 2064
Affinity Capture-Western Homo sapiens
3 LIG3 3980
Affinity Capture-MS Homo sapiens
4 RAB11FIP5 26056
Proximity Label-MS Homo sapiens
5 EXOC3 11336
Proximity Label-MS Homo sapiens
6 NOS1AP  
Proximity Label-MS Homo sapiens
7 NBEA  
Proximity Label-MS Homo sapiens
8 KRTAP10-8  
Two-hybrid Homo sapiens
9 BCAR1 9564
Reconstituted Complex Homo sapiens
10 RICTOR 253260
Proximity Label-MS Homo sapiens
11 ERBB4 2066
Two-hybrid Homo sapiens
12 C1orf226  
Proximity Label-MS Homo sapiens
13 EGFR 1956
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
14 MLH1 4292
Two-hybrid Homo sapiens
15 ERBB3 2065
Two-hybrid Homo sapiens
16 FAM195B 348262
Affinity Capture-MS Homo sapiens
17 CORO1C 23603
Affinity Capture-MS Homo sapiens
18 RAB11FIP1 80223
Proximity Label-MS Homo sapiens
19 ILKAP 80895
Affinity Capture-MS Homo sapiens
20 RALGAPB 57148
Proximity Label-MS Homo sapiens
21 LRP6 4040
Proximity Label-MS Homo sapiens
22 CNKSR1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
23 PXN 5829
Reconstituted Complex Homo sapiens
24 DHPS 1725
Two-hybrid Homo sapiens
25 KRTAP10-3  
Two-hybrid Homo sapiens
26 GHR  
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
27 ARL13B 200894
Proximity Label-MS Homo sapiens
28 LANCL1 10314
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PTPRH is involved
No pathways found





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