Gene description for Psmd14
Gene name proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
Gene symbol Psmd14
Other names/aliases 2610312C03Rik
3200001M20Rik
AA986732
Pad1
Poh1
rpm11
Species Mus musculus
 Database cross references - Psmd14
ExoCarta ExoCarta_59029
Vesiclepedia VP_59029
Entrez Gene 59029
UniProt O35593  
 Psmd14 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Psmd14
Molecular Function
    endopeptidase activity GO:0004175 ISS
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    endopeptidase activator activity GO:0061133 IEA
    endopeptidase activator activity GO:0061133 ISO
    proteasome binding GO:0070628 IBA
    proteasome binding GO:0070628 IEA
    proteasome binding GO:0070628 ISO
    metal-dependent deubiquitinase activity GO:0140492 IBA
    metal-dependent deubiquitinase activity GO:0140492 ISO
    metal-dependent deubiquitinase activity GO:0140492 ISS
Biological Process
    double-strand break repair via homologous recombination GO:0000724 ISO
    double-strand break repair via homologous recombination GO:0000724 ISS
    double-strand break repair via nonhomologous end joining GO:0006303 ISO
    double-strand break repair via nonhomologous end joining GO:0006303 ISS
    proteolysis GO:0006508 IEA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    response to ethanol GO:0045471 IEA
    regulation of proteasomal protein catabolic process GO:0061136 IEA
    regulation of proteasomal protein catabolic process GO:0061136 ISO
    protein K63-linked deubiquitination GO:0070536 ISO
    protein K63-linked deubiquitination GO:0070536 ISS
Subcellular Localization
    proteasome complex GO:0000502 IDA
    proteasome complex GO:0000502 ISO
    proteasome complex GO:0000502 ISS
    nucleus GO:0005634 IBA
    proteasome regulatory particle, lid subcomplex GO:0008541 IBA
    proteasome regulatory particle, lid subcomplex GO:0008541 ISO
    proteasome regulatory particle, lid subcomplex GO:0008541 ISS
    proteasome accessory complex GO:0022624 IDA
    cytosolic proteasome complex GO:0031597 IEA
    cytosolic proteasome complex GO:0031597 ISO
 Experiment description of studies that identified Psmd14 in sEVs
1
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Psmd14
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Psmd8 57296
Co-fractionation Mus musculus
2 Ubc  
Reconstituted Complex Mus musculus
Reconstituted Complex Mus musculus
3 Psme2 19188
Co-fractionation Mus musculus
4 Psmd2 21762
Co-fractionation Mus musculus
5 Psmb5 19173
Co-fractionation Mus musculus
6 Psmb4 19172
Affinity Capture-Western Mus musculus
7 Psmd4  
Co-fractionation Mus musculus
8 Psmd13 23997
Co-fractionation Mus musculus
9 Usp14 59025
Co-fractionation Mus musculus
10 Psmb1 19170
Co-fractionation Mus musculus
11 Atxn1  
Affinity Capture-MS Mus musculus
12 Txnl1 53382
Co-fractionation Mus musculus
13 Uba1 22201
Co-fractionation Mus musculus
14 PSMA2 5683
Affinity Capture-Western Homo sapiens
15 Vcp 269523
Co-fractionation Mus musculus
16 Psme3 19192
Co-fractionation Mus musculus
17 Psmc5 19184
Co-fractionation Mus musculus
18 Mitf  
Affinity Capture-Western Mus musculus
19 Psme4  
Co-fractionation Mus musculus
20 Tmem173  
Proximity Label-MS Mus musculus
21 Psmd7 17463
Co-fractionation Mus musculus
22 Zfand2a  
Affinity Capture-Western Mus musculus
23 Psmd3 22123
Co-fractionation Mus musculus
24 Psme1 19186
Co-fractionation Mus musculus
25 ADRM1 11047
Affinity Capture-Western Homo sapiens
26 Psmd6 66413
Co-fractionation Mus musculus
27 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Psmd14 is involved
PathwayEvidenceSource
ABC-family proteins mediated transport IEA Reactome
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins IEA Reactome
Activation of NF-kappaB in B cells IEA Reactome
Adaptive Immune System IEA Reactome
Antigen processing-Cross presentation IEA Reactome
Antigen processing: Ubiquitination & Proteasome degradation IEA Reactome
APC/C-mediated degradation of cell cycle proteins IEA Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins IEA Reactome
APC/C:Cdc20 mediated degradation of Securin IEA Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 IEA Reactome
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint IEA Reactome
Assembly of the pre-replicative complex IEA Reactome
Asymmetric localization of PCP proteins IEA Reactome
AUF1 (hnRNP D0) binds and destabilizes mRNA IEA Reactome
Autodegradation of Cdh1 by Cdh1:APC/C IEA Reactome
Autodegradation of the E3 ubiquitin ligase COP1 IEA Reactome
Beta-catenin independent WNT signaling IEA Reactome
C-type lectin receptors (CLRs) IEA Reactome
Cdc20:Phospho-APC/C mediated degradation of Cyclin A IEA Reactome
CDK-mediated phosphorylation and removal of Cdc6 IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular response to chemical stress IEA Reactome
Cellular response to hypoxia IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Class I MHC mediated antigen processing & presentation IEA Reactome
CLEC7A (Dectin-1) signaling IEA Reactome
Cross-presentation of soluble exogenous antigens (endosomes) IEA Reactome
Cyclin A:Cdk2-associated events at S phase entry IEA Reactome
Cyclin E associated events during G1/S transition IEA Reactome
Cytokine Signaling in Immune system IEA Reactome
Dectin-1 mediated noncanonical NF-kB signaling IEA Reactome
Degradation of AXIN IEA Reactome
Degradation of beta-catenin by the destruction complex IEA Reactome
Degradation of DVL IEA Reactome
Degradation of GLI1 by the proteasome IEA Reactome
Deubiquitination IEA Reactome
DNA Replication IEA Reactome
DNA Replication Pre-Initiation IEA Reactome
Downstream signaling events of B Cell Receptor (BCR) IEA Reactome
Downstream TCR signaling IEA Reactome
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis IEA Reactome
Fc epsilon receptor (FCERI) signaling IEA Reactome
FCERI mediated NF-kB activation IEA Reactome
G1/S DNA Damage Checkpoints IEA Reactome
G1/S Transition IEA Reactome
G2/M Checkpoints IEA Reactome
G2/M Transition IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
GLI3 is processed to GLI3R by the proteasome IEA Reactome
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 IEA Reactome
Hedgehog 'off' state IEA Reactome
Hedgehog 'on' state IEA Reactome
Hedgehog ligand biogenesis IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome
Interleukin-1 family signaling IEA Reactome
Interleukin-1 signaling IEA Reactome
Intracellular signaling by second messengers IEA Reactome
KEAP1-NFE2L2 pathway IEA Reactome
M Phase IEA Reactome
MAPK family signaling cascades IEA Reactome
MAPK1/MAPK3 signaling IEA Reactome
MAPK6/MAPK4 signaling IEA Reactome
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome
Metabolism of polyamines IEA Reactome
Metabolism of proteins IEA Reactome
Metabolism of RNA IEA Reactome
Metalloprotease DUBs IEA Reactome
Mitotic Anaphase IEA Reactome
Mitotic G1 phase and G1/S transition IEA Reactome
Mitotic G2-G2/M phases IEA Reactome
Mitotic Metaphase and Anaphase IEA Reactome
Neddylation IEA Reactome
Neutrophil degranulation IEA Reactome
NIK-->noncanonical NF-kB signaling IEA Reactome
Nuclear events mediated by NFE2L2 IEA Reactome
Orc1 removal from chromatin IEA Reactome
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha IEA Reactome
p53-Dependent G1 DNA Damage Response IEA Reactome
p53-Dependent G1/S DNA damage checkpoint IEA Reactome
p53-Independent DNA Damage Response IEA Reactome
p53-Independent G1/S DNA damage checkpoint IEA Reactome
PCP/CE pathway IEA Reactome
PIP3 activates AKT signaling IEA Reactome
Post-translational protein modification IEA Reactome
Proteasome assembly IEA Reactome
PTEN Regulation IEA Reactome
RAF/MAP kinase cascade IEA Reactome
Regulation of mitotic cell cycle IEA Reactome
Regulation of mRNA stability by proteins that bind AU-rich elements IEA Reactome
Regulation of ornithine decarboxylase (ODC) IEA Reactome
Regulation of PTEN stability and activity IEA Reactome
Regulation of RAS by GAPs IEA Reactome
Regulation of RUNX2 expression and activity IEA Reactome
Regulation of RUNX3 expression and activity IEA Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs IEA Reactome
S Phase IEA Reactome
SCF(Skp2)-mediated degradation of p27/p21 IEA Reactome
Separation of Sister Chromatids IEA Reactome
Signal Transduction IEA Reactome
Signaling by Hedgehog IEA Reactome
Signaling by Interleukins IEA Reactome
Signaling by the B Cell Receptor (BCR) IEA Reactome
Signaling by WNT IEA Reactome
Stabilization of p53 IEA Reactome
Switching of origins to a post-replicative state IEA Reactome
Synthesis of DNA IEA Reactome
TCF dependent signaling in response to WNT IEA Reactome
TCR signaling IEA Reactome
The role of GTSE1 in G2/M progression after G2 checkpoint IEA Reactome
TNFR2 non-canonical NF-kB pathway IEA Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional regulation by RUNX2 IEA Reactome
Transcriptional regulation by RUNX3 IEA Reactome
Transport of small molecules IEA Reactome
Ub-specific processing proteases IEA Reactome
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A IEA Reactome
Ubiquitin-dependent degradation of Cyclin D IEA Reactome
UCH proteinases IEA Reactome





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