Gene description for UBE2Q2
Gene name ubiquitin-conjugating enzyme E2Q family member 2
Gene symbol UBE2Q2
Other names/aliases -
Species Homo sapiens
 Database cross references - UBE2Q2
ExoCarta ExoCarta_92912
Vesiclepedia VP_92912
Entrez Gene 92912
HGNC 19248
MIM 612501
UniProt Q8WVN8  
 UBE2Q2 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for UBE2Q2
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ubiquitin conjugating enzyme activity GO:0061631 IBA
Biological Process
    protein K48-linked ubiquitination GO:0070936 IBA
    protein K48-linked ubiquitination GO:0070936 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified UBE2Q2 in sEVs
1
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for UBE2Q2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSN 2934
Affinity Capture-MS Homo sapiens
2 BIRC2  
Two-hybrid Homo sapiens
3 PLS1 5357
Affinity Capture-MS Homo sapiens
4 UBE2Q1 55585
Affinity Capture-MS Homo sapiens
5 WDR77 79084
Affinity Capture-MS Homo sapiens
6 ARPC2 10109
Affinity Capture-MS Homo sapiens
7 LETM1 3954
Affinity Capture-MS Homo sapiens
8 RNF31 55072
Reconstituted Complex Homo sapiens
9 DBN1 1627
Affinity Capture-MS Homo sapiens
10 RC3H2  
Reconstituted Complex Homo sapiens
11 UBC 7316
Biochemical Activity Homo sapiens
12 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
13 PRMT5 10419
Affinity Capture-MS Homo sapiens
14 MYO1C 4641
Affinity Capture-MS Homo sapiens
15 PCGF2 7703
Two-hybrid Homo sapiens
16 CAPZB 832
Affinity Capture-MS Homo sapiens
17 ARPC4 10093
Affinity Capture-MS Homo sapiens
18 RNF111 54778
Two-hybrid Homo sapiens
19 UBA1 7317
Biochemical Activity Homo sapiens
20 UBE2Q2 92912
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
21 RHOA 387
Affinity Capture-MS Homo sapiens
22 ITCH 83737
Reconstituted Complex Homo sapiens
23 ACTG1 71
Affinity Capture-MS Homo sapiens
24 MDM2  
Reconstituted Complex Homo sapiens
25 HUWE1 10075
Affinity Capture-Western Homo sapiens
26 BIRC3 330
Two-hybrid Homo sapiens
View the network image/svg+xml



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