Gene description for Flot1
Gene name	flotillin 1
Gene symbol	Flot1
Other names/aliases	reggie-2
Species	Mus musculus
Database cross references - Flot1
ExoCarta	ExoCarta_14251
Vesiclepedia	VP_14251
Entrez Gene	14251
UniProt	O08917
Flot1 identified in sEVs derived from the following tissue/cell type
Kidney medullary cells	34580290
Kidney medullary cells	34580290
Mov neuroglial cells	15210972
Serum	35173168

Gene ontology annotations for Flot1

Molecular Function     protease binding GO:0002020 IBA     protease binding GO:0002020 IEA     protease binding GO:0002020 ISO     protein binding GO:0005515 IPI     ionotropic glutamate receptor binding GO:0035255 IEA     ionotropic glutamate receptor binding GO:0035255 ISO Biological Process     positive regulation of cytokine production GO:0001819 ISO     positive regulation of protein phosphorylation GO:0001934 ISO     regulation of receptor internalization GO:0002090 IBA     regulation of receptor internalization GO:0002090 IMP     regulation of receptor internalization GO:0002090 ISO     endocytosis GO:0006897 ISO     axonogenesis GO:0007409 IMP     axon guidance GO:0007411 ISO     extracellular matrix disassembly GO:0022617 IEA     extracellular matrix disassembly GO:0022617 ISO     positive regulation of protein binding GO:0032092 IMP     positive regulation of protein binding GO:0032092 ISO     positive regulation of synaptic transmission, dopaminergic GO:0032226 IMP     positive regulation of interferon-beta production GO:0032728 IEA     positive regulation of interferon-beta production GO:0032728 ISO     dsRNA transport GO:0033227 IEA     dsRNA transport GO:0033227 ISO     positive regulation of heterotypic cell-cell adhesion GO:0034116 IEA     positive regulation of heterotypic cell-cell adhesion GO:0034116 ISO     positive regulation of toll-like receptor 3 signaling pathway GO:0034141 IEA     positive regulation of toll-like receptor 3 signaling pathway GO:0034141 ISO     response to endoplasmic reticulum stress GO:0034976 IEA     response to endoplasmic reticulum stress GO:0034976 ISO     regulation of Rho protein signal transduction GO:0035023 IMP     intracellular signal transduction GO:0035556 IMP     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO     plasma membrane raft assembly GO:0044854 IEA     plasma membrane raft assembly GO:0044854 ISO     positive regulation of endocytosis GO:0045807 IBA     positive regulation of endocytosis GO:0045807 IMP     positive regulation of endocytosis GO:0045807 ISO     positive regulation of skeletal muscle tissue development GO:0048643 IMP     positive regulation of skeletal muscle tissue development GO:0048643 ISO     protein stabilization GO:0050821 IEA     protein stabilization GO:0050821 ISO     regulation of neurotransmitter uptake GO:0051580 IEA     regulation of neurotransmitter uptake GO:0051580 ISO     protein kinase C signaling GO:0070528 IBA     protein kinase C signaling GO:0070528 ISO     cellular response to exogenous dsRNA GO:0071360 IEA     cellular response to exogenous dsRNA GO:0071360 ISO     protein localization to plasma membrane GO:0072659 IBA     protein localization to plasma membrane GO:0072659 IMP     protein localization to plasma membrane GO:0072659 IMP     protein localization to plasma membrane GO:0072659 ISO     positive regulation of myoblast fusion GO:1901741 IMP     positive regulation of myoblast fusion GO:1901741 ISO     positive regulation of cell junction assembly GO:1901890 IBA     positive regulation of cell junction assembly GO:1901890 IMP     positive regulation of cell junction assembly GO:1901890 ISO     positive regulation of cell-cell adhesion mediated by cadherin GO:2000049 IBA     positive regulation of cell-cell adhesion mediated by cadherin GO:2000049 IMP     positive regulation of cell-cell adhesion mediated by cadherin GO:2000049 ISO Subcellular Localization     uropod GO:0001931 IEA     uropod GO:0001931 ISO     endosome GO:0005768 ISO     endosome GO:0005768 ISS     early endosome GO:0005769 IEA     early endosome GO:0005769 ISO     microtubule organizing center GO:0005815 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     caveola GO:0005901 IDA     caveola GO:0005901 ISO     cell-cell junction GO:0005911 ISO     adherens junction GO:0005912 IEA     adherens junction GO:0005912 ISO     COP9 signalosome GO:0008180 IEA     COP9 signalosome GO:0008180 ISO     external side of plasma membrane GO:0009897 IDA     membrane GO:0016020 IDA     basolateral plasma membrane GO:0016323 IEA     basolateral plasma membrane GO:0016323 ISO     flotillin complex GO:0016600 IBA     flotillin complex GO:0016600 IDA     flotillin complex GO:0016600 ISO     lamellipodium GO:0030027 IEA     lamellipodium GO:0030027 ISO     cortical actin cytoskeleton GO:0030864 IEA     cortical actin cytoskeleton GO:0030864 ISO     cytoplasmic vesicle GO:0031410 IBA     cytoplasmic vesicle GO:0031410 ISO     centriolar satellite GO:0034451 IEA     centriolar satellite GO:0034451 ISO     sarcolemma GO:0042383 IDA     melanosome GO:0042470 IEA     cell-cell contact zone GO:0044291 IEA     cell-cell contact zone GO:0044291 ISO     plasma membrane raft GO:0044853 IDA     membrane raft GO:0045121 IDA     membrane raft GO:0045121 ISO     synapse GO:0045202 ISO     presynaptic active zone GO:0048786 IEA     presynaptic active zone GO:0048786 ISO     dopaminergic synapse GO:0098691 IEA     dopaminergic synapse GO:0098691 ISO     presynapse GO:0098793 ISO     glutamatergic synapse GO:0098978 IEA     glutamatergic synapse GO:0098978 ISO     GABA-ergic synapse GO:0098982 IEA     GABA-ergic synapse GO:0098982 ISO