Gene description for FANCC
Gene name Fanconi anemia, complementation group C
Gene symbol FANCC
Other names/aliases FA3
FAC
FACC
Species Homo sapiens
 Database cross references - FANCC
ExoCarta ExoCarta_2176
Vesiclepedia VP_2176
Entrez Gene 2176
HGNC 3584
MIM 613899
UniProt Q00597  
 FANCC identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for FANCC
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    myeloid cell homeostasis GO:0002262 IEA
    DNA repair GO:0006281 TAS
    nucleotide-excision repair GO:0006289 IBA
    germ cell development GO:0007281 IEA
    removal of superoxide radicals GO:0019430 IEA
    cellular response to oxidative stress GO:0034599 IBA
    interstrand cross-link repair GO:0036297 NAS
    brain morphogenesis GO:0048854 IEA
    protein-containing complex assembly GO:0065003 TAS
    neuronal stem cell population maintenance GO:0097150 IEA
Subcellular Localization
    chromatin GO:0000785 IDA
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 TAS
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    Fanconi anaemia nuclear complex GO:0043240 IBA
    Fanconi anaemia nuclear complex GO:0043240 IDA
    Fanconi anaemia nuclear complex GO:0043240 NAS
 Experiment description of studies that identified FANCC in sEVs
1
Experiment ID 237
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FANCC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSTP1 2950
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
2 Unc5a  
Affinity Capture-Western Rattus norvegicus
3 ATP6  
Two-hybrid Homo sapiens
4 RECQL5  
Synthetic Growth Defect Homo sapiens
5 POR 5447
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Two-hybrid Homo sapiens
6 SPTAN1 6709
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
7 CCNA2 890
Two-hybrid Homo sapiens
8 SPATS2L 26010
Affinity Capture-MS Homo sapiens
9 KRT1 3848
Two-hybrid Homo sapiens
10 FANCD2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 RPS3A 6189
Two-hybrid Homo sapiens
12 FANCC 2176
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 STMN2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
14 HSPA8 3312
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
15 TCERG1 10915
Two-hybrid Homo sapiens
16 STAT1 6772
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
17 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
18 FANCL 55120
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 STRA13  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
20 C1orf86  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
21 SPTA1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
22 FANCB  
Affinity Capture-MS Homo sapiens
23 USP14 9097
Two-hybrid Homo sapiens
24 OMA1  
Affinity Capture-MS Homo sapiens
25 CTBP1 1487
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
26 HSPA1A 3303
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
27 AZIN1 51582
Two-hybrid Homo sapiens
28 TMEM43 79188
Affinity Capture-MS Homo sapiens
29 HSP90B1 7184
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
30 SLTM 79811
Affinity Capture-MS Homo sapiens
31 CDK1 983
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
32 EIF2AK2 5610
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
33 OCIAD1 54940
Affinity Capture-MS Homo sapiens
34 FANCE  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
35 FANCM 57697
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
36 FANCA  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
37 IK 3550
Two-hybrid Homo sapiens
38 APITD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
39 CDH1 999
Negative Genetic Homo sapiens
40 FANCG 2189
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
41 PRDX3 10935
Two-hybrid Homo sapiens
42 PDCD11 22984
Affinity Capture-MS Homo sapiens
43 ZBTB32  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
44 HSP90AA1 3320
Two-hybrid Homo sapiens
45 FANCF  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
46 EBLN2  
Affinity Capture-MS Homo sapiens
47 HES1 3280
Affinity Capture-Western Homo sapiens
48 C17orf70  
Affinity Capture-MS Homo sapiens
49 HSPA4 3308
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
50 STMN1 3925
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
51 RPL18 6141
Two-hybrid Homo sapiens
52 NPM1 4869
Affinity Capture-Western Homo sapiens
Dosage Rescue Homo sapiens
53 CAPN10  
Two-hybrid Homo sapiens
54 CAPN1 823
Affinity Capture-Western Homo sapiens
55 DNAJB1 3337
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
56 PRPF31 26121
Two-hybrid Homo sapiens
57 NOTCH1 4851
Affinity Capture-Western Homo sapiens
58 UNC5A  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
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