Gene description for Mta2
Gene name metastasis-associated gene family, member 2
Gene symbol Mta2
Other names/aliases AW550797
Mata1l1
Mta1l1
mmta2
Species Mus musculus
 Database cross references - Mta2
ExoCarta ExoCarta_23942
Vesiclepedia VP_23942
Entrez Gene 23942
UniProt Q9R190  
 Mta2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Mta2
Molecular Function
    chromatin binding GO:0003682 IEA
    transcription coregulator activity GO:0003712 IDA
    transcription coactivator activity GO:0003713 IBA
    transcription corepressor activity GO:0003714 IBA
    histone deacetylase activity GO:0004407 IDA
    protein binding GO:0005515 IPI
    histone deacetylase binding GO:0042826 IBA
    histone deacetylase binding GO:0042826 IEA
    histone deacetylase binding GO:0042826 ISO
    sequence-specific DNA binding GO:0043565 IEA
    metal ion binding GO:0046872 IEA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IEA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    chromatin remodeling GO:0006338 ISO
    chromatin remodeling GO:0006338 TAS
    regulation of fibroblast migration GO:0010762 IEA
    regulation of fibroblast migration GO:0010762 ISO
    regulation of cell fate specification GO:0042659 NAS
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 NAS
    positive regulation of DNA-templated transcription GO:0045893 NAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    chromosome organization GO:0051276 TAS
    genomic imprinting GO:0071514 IMP
    regulation of stem cell differentiation GO:2000736 NAS
Subcellular Localization
    histone deacetylase complex GO:0000118 IDA
    chromosome, telomeric region GO:0000781 IEA
    chromosome, telomeric region GO:0000781 ISO
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 ISO
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 ISO
    NuRD complex GO:0016581 IBA
    NuRD complex GO:0016581 IDA
    NuRD complex GO:0016581 IPI
    NuRD complex GO:0016581 ISO
    NuRD complex GO:0016581 NAS
 Experiment description of studies that identified Mta2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Mta2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GATAD2A 54815
Affinity Capture-MS Homo sapiens
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Esrrb  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
4 ZNF292  
Affinity Capture-MS Homo sapiens
5 CNTRL  
Affinity Capture-MS Homo sapiens
6 RHOF 54509
Affinity Capture-MS Homo sapiens
7 GATAD2B 57459
Affinity Capture-MS Homo sapiens
8 KPNA3 3839
Affinity Capture-MS Homo sapiens
9 HDAC2 3066
Affinity Capture-MS Homo sapiens
10 EOGT 285203
Affinity Capture-MS Homo sapiens
11 Klf5  
Affinity Capture-Western Mus musculus
12 Pou5f1  
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
13 Hdac2  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
14 Chd4 107932
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
15 MTA1 9112
Affinity Capture-MS Homo sapiens
16 ODF2 4957
Affinity Capture-MS Homo sapiens
17 JADE1  
Affinity Capture-MS Homo sapiens
18 HIST2H2AA3 8337
Affinity Capture-MS Homo sapiens
19 Gata1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
20 Satb2  
Affinity Capture-Western Mus musculus
21 Atxn1  
Affinity Capture-MS Mus musculus
22 RBBP7 5931
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
23 Cebpa  
Affinity Capture-MS Mus musculus
24 Runx1 12394
Affinity Capture-MS Mus musculus
25 Tfe3  
Affinity Capture-MS Mus musculus
26 Rbbp7 245688
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
27 HDAC1 3065
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
28 CHD4 1108
Affinity Capture-MS Homo sapiens
29 RBBP4 5928
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
30 Zfpm1  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
31 Mta1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
32 Mbd3  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
33 CPEB2  
Affinity Capture-MS Homo sapiens
34 PTCD3 55037
Affinity Capture-MS Homo sapiens
35 Hdac1 433759
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
36 SMARCA4 6597
Affinity Capture-MS Homo sapiens
37 Mbd2  
Affinity Capture-Western Mus musculus
38 Mta2 23942
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
39 Unk  
Affinity Capture-RNA Mus musculus
40 Nanog  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
41 Tfcp2l1  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
42 CDK2AP1  
Affinity Capture-MS Homo sapiens
43 MBD2 8932
Affinity Capture-MS Homo sapiens
44 FAM134C 162427
Affinity Capture-MS Homo sapiens
45 Zbtb7b  
Affinity Capture-MS Mus musculus
46 MTA3 57504
Affinity Capture-MS Homo sapiens
47 Rbbp4 19646
Affinity Capture-Western Mus musculus
48 Eed  
Affinity Capture-MS Mus musculus
49 CHAF1B  
Affinity Capture-MS Homo sapiens
50 MBD3 53615
Affinity Capture-MS Homo sapiens
51 Atg16l1  
Affinity Capture-MS Mus musculus
52 Sall4  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
53 Atg12  
Positive Genetic Mus musculus
54 ERAL1  
Affinity Capture-MS Homo sapiens
55 EEF1G 1937
Affinity Capture-MS Homo sapiens
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