Gene description for ACOT11
Gene name acyl-CoA thioesterase 11
Gene symbol ACOT11
Other names/aliases BFIT
STARD14
THEA
THEM1
Species Homo sapiens
 Database cross references - ACOT11
ExoCarta ExoCarta_26027
Vesiclepedia VP_26027
Entrez Gene 26027
HGNC 18156
MIM 606803
UniProt Q8WXI4  
 ACOT11 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ACOT11
Molecular Function
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
    fatty acyl-CoA hydrolase activity GO:0047617 IDA
    fatty acyl-CoA hydrolase activity GO:0047617 TAS
    carboxylic ester hydrolase activity GO:0052689 IEA
    long-chain fatty acyl-CoA hydrolase activity GO:0052816 IBA
    long-chain fatty acyl-CoA hydrolase activity GO:0052816 IDA
Biological Process
    fatty acid metabolic process GO:0006631 IEA
    fatty acid metabolic process GO:0006631 NAS
    acyl-CoA metabolic process GO:0006637 IBA
    response to temperature stimulus GO:0009266 ISS
    response to cold GO:0009409 ISS
    intracellular signal transduction GO:0035556 NAS
    negative regulation of cold-induced thermogenesis GO:0120163 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    mitochondrial matrix GO:0005759 IDA
    mitochondrial matrix GO:0005759 IEA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified ACOT11 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ACOT11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TUBA1A 7846
Affinity Capture-MS Homo sapiens
2 GEMIN6  
Two-hybrid Homo sapiens
3 ACOT11 26027
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
4 MAGEB4  
Two-hybrid Homo sapiens
5 DPP9 91039
Affinity Capture-MS Homo sapiens
6 HGS 9146
Two-hybrid Homo sapiens
7 FGFBP2  
Affinity Capture-MS Homo sapiens
8 MKRN3  
Two-hybrid Homo sapiens
9 ACOT12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TEKT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 FKBP7 51661
Affinity Capture-MS Homo sapiens
12 ALS2CR11  
Two-hybrid Homo sapiens
13 THUMPD3 25917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 RTKN 6242
Affinity Capture-MS Homo sapiens
15 CABP5  
Two-hybrid Homo sapiens
16 SUOX  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ACOT11 is involved
PathwayEvidenceSource
Fatty acid metabolism TAS Reactome
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Mitochondrial Fatty Acid Beta-Oxidation TAS Reactome





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