Gene description for PLXDC2
Gene name plexin domain containing 2
Gene symbol PLXDC2
Other names/aliases TEM7R
Species Homo sapiens
 Database cross references - PLXDC2
ExoCarta ExoCarta_84898
Vesiclepedia VP_84898
Entrez Gene 84898
HGNC 21013
MIM 606827
UniProt Q6UX71  
 PLXDC2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Prostate cancer cells 25844599    
 Gene ontology annotations for PLXDC2
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    membrane GO:0016020 IEA
 Experiment description of studies that identified PLXDC2 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 275
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for PLXDC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBR2 23304
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 LAMTOR5 10542
Affinity Capture-MS Homo sapiens
3 PIP5K1A 8394
Affinity Capture-MS Homo sapiens
4 RELA 5970
Affinity Capture-MS Homo sapiens
5 LYPD6B 130576
Affinity Capture-MS Homo sapiens
6 CD28  
Affinity Capture-MS Homo sapiens
7 PNPLA6 10908
Affinity Capture-MS Homo sapiens
8 HACL1 26061
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 NPTX1  
Affinity Capture-MS Homo sapiens
10 VDR  
Affinity Capture-MS Homo sapiens
11 UFSP2 55325
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 RARS2  
Affinity Capture-MS Homo sapiens
13 TTC17 55761
Affinity Capture-MS Homo sapiens
14 UPK3BL 100134938
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 LRRC42  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CCDC115 84317
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 LARP4B 23185
Affinity Capture-MS Homo sapiens
18 DHRS7 51635
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 ZFYVE27 118813
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 C1orf186  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 MANEAL 149175
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TMEM255B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 CTDNEP1 23399
Affinity Capture-MS Homo sapiens
24 TMEM199  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 PYY  
Affinity Capture-MS Homo sapiens
26 TRAT1 50852
Affinity Capture-MS Homo sapiens
27 IGFBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 ZBP1  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
29 PICK1  
Affinity Capture-MS Homo sapiens
30 INSL5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ATG4C  
Affinity Capture-MS Homo sapiens
32 KLHL11  
Affinity Capture-MS Homo sapiens
33 ATP6V1F 9296
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 AKR1C4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 AKR1D1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 NRBP1 29959
Affinity Capture-MS Homo sapiens
37 IBSP  
Affinity Capture-MS Homo sapiens
38 FAM9A  
Affinity Capture-MS Homo sapiens
39 KCNJ8  
Affinity Capture-MS Homo sapiens
40 UBE2K 3093
Affinity Capture-MS Homo sapiens
41 SERPINB8 5271
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 DNAJB9 4189
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 RANGRF  
Affinity Capture-MS Homo sapiens
44 NDUFA10 4705
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 GCSAML  
Affinity Capture-MS Homo sapiens
46 SLC31A1 1317
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 TMEM131  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 BOD1  
Affinity Capture-MS Homo sapiens
49 SSC5D 284297
Affinity Capture-MS Homo sapiens
50 ZCWPW1 55063
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PLXDC2 is involved
No pathways found





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