Gene description for MTMR2
Gene name myotubularin related protein 2
Gene symbol MTMR2
Other names/aliases CMT4B
CMT4B1
Species Homo sapiens
 Database cross references - MTMR2
ExoCarta ExoCarta_8898
Vesiclepedia VP_8898
Entrez Gene 8898
HGNC 7450
MIM 603557
UniProt Q13614  
 MTMR2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for MTMR2
Molecular Function
    phosphatidylinositol-3-phosphate phosphatase activity GO:0004438 IBA
    phosphatidylinositol-3-phosphate phosphatase activity GO:0004438 IDA
    phosphatidylinositol-3-phosphate phosphatase activity GO:0004438 TAS
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IEA
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO:0052629 IBA
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO:0052629 IDA
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO:0052629 TAS
Biological Process
    negative regulation of receptor internalization GO:0002091 ISS
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    negative regulation of myelination GO:0031642 IEA
    myelin assembly GO:0032288 IEA
    negative regulation of endocytosis GO:0045806 ISS
    phosphatidylinositol dephosphorylation GO:0046856 IBA
    phosphatidylinositol dephosphorylation GO:0046856 IDA
    neuron development GO:0048666 IEA
    regulation of phosphatidylinositol dephosphorylation GO:0060304 IDA
    negative regulation of excitatory postsynaptic potential GO:0090394 ISS
    dendritic spine maintenance GO:0097062 ISS
    positive regulation of early endosome to late endosome transport GO:2000643 ISS
    negative regulation of receptor catabolic process GO:2000645 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    vacuolar membrane GO:0005774 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISS
    cytosol GO:0005829 TAS
    synaptic vesicle GO:0008021 ISS
    postsynaptic density GO:0014069 ISS
    membrane GO:0016020 IBA
    axon GO:0030424 ISS
    dendrite GO:0030425 ISS
    early endosome membrane GO:0031901 IEA
    dendritic spine GO:0043197 ISS
    intracellular membrane-bounded organelle GO:0043231 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    extracellular exosome GO:0070062 HDA
    synaptic membrane GO:0097060 ISS
 Experiment description of studies that identified MTMR2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for MTMR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SCHIP1  
Affinity Capture-MS Homo sapiens
2 MTMR10 54893
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 RPL3L 6123
Affinity Capture-MS Homo sapiens
4 CPSF6 11052
Affinity Capture-MS Homo sapiens
5 MRTO4 51154
Affinity Capture-MS Homo sapiens
6 EHD4 30844
Co-fractionation Homo sapiens
7 CTPS2 56474
Co-fractionation Homo sapiens
8 RPS19BP1  
Affinity Capture-MS Homo sapiens
9 UNK  
Affinity Capture-RNA Homo sapiens
10 YWHAE 7531
Affinity Capture-MS Homo sapiens
11 S100A2 6273
Affinity Capture-MS Homo sapiens
12 ERBB4 2066
Two-hybrid Homo sapiens
13 RFC5 5985
Co-fractionation Homo sapiens
14 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
15 MTMR11  
Affinity Capture-MS Homo sapiens
16 SBF2 81846
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 ERBB3 2065
Two-hybrid Homo sapiens
18 SBF1 6305
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 MTRF1  
Affinity Capture-MS Homo sapiens
20 MTMR9 66036
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 ROR2 4920
Two-hybrid Homo sapiens
22 G6PD 2539
Affinity Capture-MS Homo sapiens
23 EBNA1BP2 10969
Affinity Capture-MS Homo sapiens
24 GADD45GIP1  
Affinity Capture-MS Homo sapiens
25 EPHA2 1969
Proximity Label-MS Homo sapiens
26 MTMR12 54545
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 TUBA1B 10376
Affinity Capture-MS Homo sapiens
28 LUC7L3 51747
Affinity Capture-MS Homo sapiens
29 HSF1  
Co-fractionation Homo sapiens
30 NUDT16 131870
Affinity Capture-MS Homo sapiens
31 COX7A2 1347
Affinity Capture-MS Homo sapiens
32 PLIN3 10226
Co-fractionation Homo sapiens
33 NFKB1 4790
Affinity Capture-MS Homo sapiens
34 EYA3  
Affinity Capture-MS Homo sapiens
35 BICD2 23299
Proximity Label-MS Homo sapiens
36 MTMR1 8776
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 CCDC22 28952
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 MTMR2 8898
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
39 SEPSECS  
Affinity Capture-MS Homo sapiens
40 OBSL1 23363
Affinity Capture-MS Homo sapiens
41 PML 5371
Affinity Capture-MS Homo sapiens
42 DR1  
Affinity Capture-MS Homo sapiens
43 LRSAM1 90678
Co-fractionation Homo sapiens
44 C20orf24  
Affinity Capture-MS Homo sapiens
45 XPNPEP1 7511
Co-fractionation Homo sapiens
46 SZRD1 26099
Co-fractionation Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here