Gene description for MTMR6
Gene name myotubularin related protein 6
Gene symbol MTMR6
Other names/aliases -
Species Homo sapiens
 Database cross references - MTMR6
ExoCarta ExoCarta_9107
Vesiclepedia VP_9107
Entrez Gene 9107
HGNC 7453
MIM 603561
UniProt Q9Y217  
 MTMR6 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MTMR6
Molecular Function
    phosphatidylinositol-3-phosphate phosphatase activity GO:0004438 IBA
    phosphatidylinositol-3-phosphate phosphatase activity GO:0004438 IDA
    phosphatidylinositol-3-phosphate phosphatase activity GO:0004438 TAS
    protein serine/threonine phosphatase activity GO:0004722 NAS
    protein tyrosine phosphatase activity GO:0004725 NAS
    protein binding GO:0005515 IPI
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO:0052629 TAS
    phosphatidylinositol-3,5-bisphosphate phosphatase activity GO:0106018 IBA
    phosphatidylinositol-3,5-bisphosphate phosphatase activity GO:0106018 IDA
Biological Process
    protein dephosphorylation GO:0006470 NAS
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    endocytosis GO:0006897 IEA
    phosphatidylinositol dephosphorylation GO:0046856 IBA
    phosphatidylinositol dephosphorylation GO:0046856 IDA
Subcellular Localization
    nuclear envelope GO:0005635 IBA
    nuclear envelope GO:0005635 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IEA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IEA
    cytosol GO:0005829 TAS
    ruffle membrane GO:0032587 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified MTMR6 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MTMR6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF43  
Proximity Label-MS Homo sapiens
2 ZWINT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CTSE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 AATK  
Two-hybrid Homo sapiens
5 STK25 10494
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 BHMT 635
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 EBAG9 9166
Proximity Label-MS Homo sapiens
8 NMI  
Two-hybrid Homo sapiens
9 LAMTOR1 55004
Proximity Label-MS Homo sapiens
10 RNF181  
Affinity Capture-MS Homo sapiens
11 RAB5A 5868
Proximity Label-MS Homo sapiens
12 CDA 978
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 BAG2 9532
Affinity Capture-MS Homo sapiens
14 MTNR1B  
Two-hybrid Homo sapiens
15 DDHD1 80821
Affinity Capture-MS Homo sapiens
16 RAB9A 9367
Proximity Label-MS Homo sapiens
17 TTR 7276
Affinity Capture-MS Homo sapiens
18 MID1IP1  
Affinity Capture-MS Homo sapiens
19 IFI30  
Affinity Capture-MS Homo sapiens
20 TIMM10  
Affinity Capture-MS Homo sapiens
21 LMTK2 22853
Two-hybrid Homo sapiens
22 ERBB4 2066
Two-hybrid Homo sapiens
23 BBS7 55212
Affinity Capture-MS Homo sapiens
24 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
25 PARK2  
Affinity Capture-MS Homo sapiens
26 ANKRD39  
Affinity Capture-MS Homo sapiens
27 ERBB3 2065
Two-hybrid Homo sapiens
28 TMEM159 57146
Affinity Capture-MS Homo sapiens
29 RARG  
Two-hybrid Homo sapiens
30 HIP1R 9026
Co-fractionation Homo sapiens
31 MTMR9 66036
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
32 RPL34 6164
Affinity Capture-MS Homo sapiens
33 ROR2 4920
Two-hybrid Homo sapiens
34 RAB4A 5867
Proximity Label-MS Homo sapiens
35 AMOTL2 51421
Two-hybrid Homo sapiens
36 RPA3 6119
Proximity Label-MS Homo sapiens
37 BRCA2 675
Affinity Capture-MS Homo sapiens
38 SOAT1 6646
Affinity Capture-MS Homo sapiens
39 CARM1 10498
Affinity Capture-MS Homo sapiens
40 MTMR7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 HSPA2 3306
Affinity Capture-MS Homo sapiens
42 RAB11A 8766
Proximity Label-MS Homo sapiens
43 TRIM27  
Two-hybrid Homo sapiens
44 RAB3B 5865
Proximity Label-MS Homo sapiens
45 KCTD17 79734
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 ACTB 60
Proximity Label-MS Homo sapiens
47 FHIT 2272
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 BICD2 23299
Proximity Label-MS Homo sapiens
49 ATG9A 79065
Proximity Label-MS Homo sapiens
50 CUEDC1 404093
Affinity Capture-MS Homo sapiens
51 MTUS2 23281
Two-hybrid Homo sapiens
52 PCYT1A 5130
Affinity Capture-MS Homo sapiens
53 KCNJ5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 PMS2P3  
Affinity Capture-MS Homo sapiens
55 DDX55  
Affinity Capture-MS Homo sapiens
56 STX6 10228
Proximity Label-MS Homo sapiens
57 PTK7 5754
Two-hybrid Homo sapiens
58 MTMR6 9107
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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