Gene description for SLC33A1
Gene name solute carrier family 33 (acetyl-CoA transporter), member 1
Gene symbol SLC33A1
Other names/aliases ACATN
AT-1
AT1
CCHLND
SPG42
Species Homo sapiens
 Database cross references - SLC33A1
ExoCarta ExoCarta_9197
Vesiclepedia VP_9197
Entrez Gene 9197
HGNC 95
MIM 603690
UniProt O00400  
 SLC33A1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SLC33A1
Molecular Function
    protein binding GO:0005515 IPI
    acetyl-CoA transmembrane transporter activity GO:0008521 IDA
    acetyl-CoA transmembrane transporter activity GO:0008521 TAS
    protein homodimerization activity GO:0042803 IDA
Biological Process
    acetyl-CoA transmembrane transport GO:0035348 IDA
    transmembrane transport GO:0055085 TAS
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    endoplasmic reticulum membrane GO:0005789 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 HDA
 Experiment description of studies that identified SLC33A1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
6
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SLC33A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RIT1 6016
Negative Genetic Homo sapiens
2 GJD3  
Proximity Label-MS Homo sapiens
3 CLCN7 1186
Affinity Capture-MS Homo sapiens
4 RAD51  
Affinity Capture-MS Homo sapiens
5 MAT2A 4144
Affinity Capture-MS Homo sapiens
6 EEF1G 1937
Affinity Capture-MS Homo sapiens
7 METTL7A 25840
Proximity Label-MS Homo sapiens
8 LAMP3  
Proximity Label-MS Homo sapiens
9 TMEM184A  
Affinity Capture-MS Homo sapiens
10 BSCL2  
Affinity Capture-MS Homo sapiens
11 SLC2A1 6513
Affinity Capture-MS Homo sapiens
12 HSD17B11 51170
Proximity Label-MS Homo sapiens
13 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
14 LAMP2 3920
Proximity Label-MS Homo sapiens
15 DNAJC25 548645
Proximity Label-MS Homo sapiens
16 PTPN1 5770
Proximity Label-MS Homo sapiens
17 STX4 6810
Proximity Label-MS Homo sapiens
18 FFAR1  
Affinity Capture-MS Homo sapiens
19 B3GAT1  
Proximity Label-MS Homo sapiens
20 UBE2O 63893
Affinity Capture-MS Homo sapiens
21 METTL8  
Affinity Capture-MS Homo sapiens
22 RAB3B 5865
Proximity Label-MS Homo sapiens
23 SLC27A2 11001
Affinity Capture-MS Homo sapiens
24 MST1R 4486
Affinity Capture-MS Homo sapiens
25 SSR1 6745
Proximity Label-MS Homo sapiens
26 GPBAR1  
Affinity Capture-MS Homo sapiens
27 ATP5O 539
Affinity Capture-MS Homo sapiens
28 KRAS 3845
Negative Genetic Homo sapiens
29 PDF  
Affinity Capture-MS Homo sapiens
30 KIAA0368 23392
Affinity Capture-MS Homo sapiens
31 INADL 10207
Affinity Capture-MS Homo sapiens
32 ZNF598 90850
Affinity Capture-MS Homo sapiens
33 RAD50 10111
Affinity Capture-MS Homo sapiens
34 EBAG9 9166
Proximity Label-MS Homo sapiens
35 FAM20C 56975
Affinity Capture-MS Homo sapiens
36 GPR17 2840
Affinity Capture-MS Homo sapiens
37 MARCKS 4082
Proximity Label-MS Homo sapiens
38 NUP155 9631
Proximity Label-MS Homo sapiens
39 KIAA1715 80856
Proximity Label-MS Homo sapiens
40 PFN1 5216
Affinity Capture-MS Homo sapiens
41 NF2 4771
Affinity Capture-MS Homo sapiens
42 PANX1 24145
Proximity Label-MS Homo sapiens
43 ATP5A1 498
Affinity Capture-MS Homo sapiens
44 EMD 2010
Proximity Label-MS Homo sapiens
45 RAB14 51552
Affinity Capture-MS Homo sapiens
46 PARK2  
Affinity Capture-MS Homo sapiens
47 CXADR 1525
Proximity Label-MS Homo sapiens
48 NUDT18  
Affinity Capture-MS Homo sapiens
49 HSP90B1 7184
Affinity Capture-MS Homo sapiens
50 ILVBL 10994
Affinity Capture-MS Homo sapiens
51 GPR35  
Affinity Capture-MS Homo sapiens
52 ACACA 31
Negative Genetic Homo sapiens
53 GIT1 28964
Affinity Capture-MS Homo sapiens
54 GPR182  
Affinity Capture-MS Homo sapiens
55 RPN1 6184
Proximity Label-MS Homo sapiens
56 RHOT2 89941
Proximity Label-MS Homo sapiens
57 ELOVL5 60481
Proximity Label-MS Homo sapiens
58 ATP5E 514
Affinity Capture-MS Homo sapiens
59 SEC61B 10952
Proximity Label-MS Homo sapiens
60 SLC7A1 6541
Affinity Capture-MS Homo sapiens
61 REEP5 7905
Proximity Label-MS Homo sapiens
62 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 ELMO3 79767
Affinity Capture-MS Homo sapiens
64 RPN2 6185
Proximity Label-MS Homo sapiens
65 CANX 821
Affinity Capture-MS Homo sapiens
66 LRRC59 55379
Proximity Label-MS Homo sapiens
67 LMNB1 4001
Proximity Label-MS Homo sapiens
68 LAMP1 3916
Proximity Label-MS Homo sapiens
69 C19orf43  
Affinity Capture-MS Homo sapiens
70 BCAP31 10134
Proximity Label-MS Homo sapiens
71 HSD3B7 80270
Proximity Label-MS Homo sapiens
72 STIM1 6786
Proximity Label-MS Homo sapiens
73 CKAP2  
Affinity Capture-MS Homo sapiens
74 EGFR 1956
Negative Genetic Homo sapiens
75 FKBP8 23770
Proximity Label-MS Homo sapiens
76 ARF6 382
Proximity Label-MS Homo sapiens
77 AQP3  
Affinity Capture-MS Homo sapiens
78 OPRL1 4987
Affinity Capture-MS Homo sapiens
79 ENTPD7  
Affinity Capture-MS Homo sapiens
80 TRAPPC1 58485
Affinity Capture-MS Homo sapiens
81 ZW10 9183
Affinity Capture-MS Homo sapiens
82 RBM42  
Affinity Capture-MS Homo sapiens
83 NAAA  
Affinity Capture-MS Homo sapiens
84 MSL1 339287
Affinity Capture-MS Homo sapiens
85 GPR45  
Affinity Capture-MS Homo sapiens
86 RAB9A 9367
Proximity Label-MS Homo sapiens
87 USP24 23358
Affinity Capture-MS Homo sapiens
88 NCLN 56926
Affinity Capture-MS Homo sapiens
89 TCEB2 6923
Affinity Capture-MS Homo sapiens
90 DHFRL1  
Proximity Label-MS Homo sapiens
91 CYP2C9  
Proximity Label-MS Homo sapiens
92 HAX1  
Affinity Capture-MS Homo sapiens
93 SLC22A4 6583
Affinity Capture-MS Homo sapiens
94 LMNA 4000
Proximity Label-MS Homo sapiens
95 DOCK6 57572
Affinity Capture-MS Homo sapiens
96 TPM4 7171
Affinity Capture-MS Homo sapiens
97 CEPT1 10390
Affinity Capture-MS Homo sapiens
98 PHGDH 26227
Affinity Capture-MS Homo sapiens
99 IMMT 10989
Affinity Capture-MS Homo sapiens
100 ARHGEF7 8874
Affinity Capture-MS Homo sapiens
101 CLPP 8192
Proximity Label-MS Homo sapiens
102 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
103 FASN 2194
Negative Genetic Homo sapiens
104 CLIC1 1192
Affinity Capture-MS Homo sapiens
105 TMEM57  
Affinity Capture-MS Homo sapiens
106 MCAT 27349
Affinity Capture-MS Homo sapiens
107 SNUPN 10073
Affinity Capture-MS Homo sapiens
108 ERGIC1 57222
Proximity Label-MS Homo sapiens
109 ATP2A2 488
Affinity Capture-MS Homo sapiens
110 MKI67  
Affinity Capture-MS Homo sapiens
111 RAB4A 5867
Proximity Label-MS Homo sapiens
112 SEMA3B 7869
Affinity Capture-MS Homo sapiens
113 ERGIC2 51290
Proximity Label-MS Homo sapiens
114 PLD3 23646
Affinity Capture-MS Homo sapiens
115 RAB2A 5862
Proximity Label-MS Homo sapiens
116 TAGLN2 8407
Affinity Capture-MS Homo sapiens
117 SEC62 7095
Proximity Label-MS Homo sapiens
118 EEF1D 1936
Affinity Capture-MS Homo sapiens
119 RAB7A 7879
Proximity Label-MS Homo sapiens
120 RAB11A 8766
Proximity Label-MS Homo sapiens
121 MYO1E 4643
Affinity Capture-MS Homo sapiens
122 SERBP1 26135
Affinity Capture-MS Homo sapiens
123 DNAJC1 64215
Proximity Label-MS Homo sapiens
124 VIPR1  
Affinity Capture-MS Homo sapiens
125 RAB5C 5878
Proximity Label-MS Homo sapiens
126 TAP1 6890
Affinity Capture-MS Homo sapiens
127 CKAP4 10970
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 DERL1 79139
Proximity Label-MS Homo sapiens
129 ATP2A1 487
Proximity Label-MS Homo sapiens
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