Gene description for ZNF598
Gene name zinc finger protein 598
Gene symbol ZNF598
Other names/aliases -
Species Homo sapiens
 Database cross references - ZNF598
ExoCarta ExoCarta_90850
Vesiclepedia VP_90850
Entrez Gene 90850
HGNC 28079
UniProt Q86UK7  
 ZNF598 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ZNF598
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    ribosome binding GO:0043022 IBA
    ribosome binding GO:0043022 IDA
    metal ion binding GO:0046872 IEA
    ubiquitin-protein transferase regulator activity GO:0055106 IDA
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IDA
    ubiquitin protein ligase activity GO:0061630 IMP
    protein-RNA adaptor activity GO:0140517 IDA
    stalled ribosome sensor activity GO:0170011 IDA
Biological Process
    protein monoubiquitination GO:0006513 IDA
    protein ubiquitination GO:0016567 IBA
    protein ubiquitination GO:0016567 IMP
    negative regulation of translational initiation GO:0045947 IDA
    protein K63-linked ubiquitination GO:0070534 IDA
    rescue of stalled ribosome GO:0072344 IBA
    rescue of stalled ribosome GO:0072344 IDA
    rescue of stalled ribosome GO:0072344 IMP
    ribosome-associated ubiquitin-dependent protein catabolic process GO:1990116 IMP
Subcellular Localization
    cytosol GO:0005829 IDA
    cytosolic ribosome GO:0022626 IDA
 Experiment description of studies that identified ZNF598 in sEVs
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ZNF598
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRMT1 55621
Co-fractionation Homo sapiens
2 Rpl35 66489
Affinity Capture-MS Mus musculus
3 TPX2  
Co-fractionation Homo sapiens
4 UBE2H 7328
Affinity Capture-MS Homo sapiens
5 USP2  
Affinity Capture-MS Homo sapiens
6 UBE2S  
Co-fractionation Homo sapiens
7 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
8 GIGYF2 26058
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 STK25 10494
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 BAG2 9532
Affinity Capture-MS Homo sapiens
11 CUL3 8452
Affinity Capture-MS Homo sapiens
12 GSK3B 2932
Affinity Capture-MS Homo sapiens
13 TP53 7157
Affinity Capture-MS Homo sapiens
14 OTUD1 220213
Affinity Capture-MS Homo sapiens
15 YWHAZ 7534
Affinity Capture-MS Homo sapiens
16 NINL  
Proximity Label-MS Homo sapiens
17 WWOX 51741
Affinity Capture-MS Homo sapiens
18 PRMT1 3276
Affinity Capture-MS Homo sapiens
19 RPA2 6118
Affinity Capture-MS Homo sapiens
20 UBE2L3 7332
Affinity Capture-MS Homo sapiens
21 DIS3L  
Affinity Capture-MS Homo sapiens
22 RPA1 6117
Affinity Capture-MS Homo sapiens
23 YWHAE 7531
Affinity Capture-MS Homo sapiens
24 RPS16 6217
Affinity Capture-MS Homo sapiens
25 AJUBA  
Affinity Capture-MS Homo sapiens
26 RPL10 6134
Affinity Capture-MS Homo sapiens
27 SERBP1 26135
Proximity Label-MS Homo sapiens
28 USP9X 8239
Affinity Capture-Western Homo sapiens
29 USP11 8237
Affinity Capture-MS Homo sapiens
30 INSIG2  
Affinity Capture-MS Homo sapiens
31 Clasp2  
Affinity Capture-MS Mus musculus
32 MAPRE3  
Proximity Label-MS Homo sapiens
33 Actb 11461
Affinity Capture-MS Mus musculus
34 PRPF40A 55660
Affinity Capture-MS Homo sapiens
35 KBTBD7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 EIF4E2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
37 FOXS1  
Affinity Capture-MS Homo sapiens
38 MAPRE1 22919
Affinity Capture-MS Homo sapiens
39 ESR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
40 APEX1 328
Affinity Capture-RNA Homo sapiens
41 CXCL8 3576
Protein-RNA Homo sapiens
Affinity Capture-RNA Homo sapiens
42 UBD  
Affinity Capture-Western Homo sapiens
43 MAP2K3 5606
Affinity Capture-MS Homo sapiens
44 RPS20 6224
Proximity Label-MS Homo sapiens
45 RPS24 6229
Proximity Label-MS Homo sapiens
46 PSPC1 55269
Affinity Capture-MS Homo sapiens
47 DARS 1615
Co-fractionation Homo sapiens
48 NIN 51199
Proximity Label-MS Homo sapiens
49 HSPA2 3306
Affinity Capture-MS Homo sapiens
50 NTRK1 4914
Affinity Capture-MS Homo sapiens
51 GIGYF1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
52 Rrbp1  
Affinity Capture-MS Mus musculus
53 SYNCRIP 10492
Co-fractionation Homo sapiens
54 MB21D1  
Proximity Label-MS Homo sapiens
55 DCTN1 1639
Proximity Label-MS Homo sapiens
56 Cdc6 23834
Affinity Capture-MS Mus musculus
57 FBXW7  
Affinity Capture-MS Homo sapiens
58 POC1B 282809
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 FBXL6  
Affinity Capture-Western Homo sapiens
60 HDLBP 3069
Co-fractionation Homo sapiens
61 BICD2 23299
Proximity Label-MS Homo sapiens
62 EIF3B 8662
Affinity Capture-MS Homo sapiens
63 TGM1 7051
Affinity Capture-MS Homo sapiens
64 XRCC3  
Affinity Capture-MS Homo sapiens
65 SLC31A1 1317
Affinity Capture-MS Homo sapiens
66 PAK7  
Affinity Capture-MS Homo sapiens
67 DDX58 23586
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-RNA Homo sapiens
68 RPA3 6119
Affinity Capture-MS Homo sapiens
69 GNB2L1 10399
Affinity Capture-MS Homo sapiens
70 SLC33A1 9197
Affinity Capture-MS Homo sapiens
71 RMDN3 55177
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZNF598 is involved
No pathways found





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