Gene description for TGM1
Gene name transglutaminase 1
Gene symbol TGM1
Other names/aliases ARCI1
ICR2
KTG
LI
LI1
TGASE
TGK
Species Homo sapiens
 Database cross references - TGM1
ExoCarta ExoCarta_7051
Vesiclepedia VP_7051
Entrez Gene 7051
HGNC 11777
MIM 190195
UniProt P22735  
 TGM1 identified in sEVs derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for TGM1
Molecular Function
    protein-glutamine gamma-glutamyltransferase activity GO:0003810 IBA
    protein-glutamine gamma-glutamyltransferase activity GO:0003810 IDA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    positive regulation of keratinocyte proliferation GO:0010838 IMP
    peptide cross-linking GO:0018149 IDA
    keratinocyte differentiation GO:0030216 IBA
    keratinocyte differentiation GO:0030216 IDA
    keratinization GO:0031424 IEA
    protein modification process GO:0036211 NAS
    cell envelope organization GO:0043163 TAS
    positive regulation of cell cycle GO:0045787 IMP
Subcellular Localization
    cornified envelope GO:0001533 TAS
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified TGM1 in sEVs
1
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for TGM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 NFAM1  
Affinity Capture-MS Homo sapiens
3 TNFAIP3 7128
Affinity Capture-MS Homo sapiens
4 EIF4G3 8672
Affinity Capture-MS Homo sapiens
5 CCDC103  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 RPS19BP1  
Affinity Capture-MS Homo sapiens
7 TCTN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 MBD4  
Affinity Capture-MS Homo sapiens
9 OXSR1 9943
Affinity Capture-MS Homo sapiens
10 SMG7  
Affinity Capture-MS Homo sapiens
11 EBF2  
Affinity Capture-MS Homo sapiens
12 ZIC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 RBM12 10137
Affinity Capture-MS Homo sapiens
14 ST7  
Affinity Capture-MS Homo sapiens
15 EIF4E2  
Affinity Capture-MS Homo sapiens
16 RFX1  
Affinity Capture-MS Homo sapiens
17 FNDC5  
Affinity Capture-MS Homo sapiens
18 PI4KA 5297
Affinity Capture-MS Homo sapiens
19 RHBDD1 84236
Affinity Capture-MS Homo sapiens
20 SATB2  
Affinity Capture-MS Homo sapiens
21 CREBBP  
Affinity Capture-MS Homo sapiens
22 APEX1 328
Affinity Capture-RNA Homo sapiens
23 DPPA4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 GPATCH2L  
Affinity Capture-MS Homo sapiens
25 L2HGDH  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 B3GNT2 10678
Affinity Capture-MS Homo sapiens
27 MCM2 4171
Affinity Capture-MS Homo sapiens
28 TBL1XR1 79718
Affinity Capture-MS Homo sapiens
29 TLN1 7094
Affinity Capture-MS Homo sapiens
30 E2F6 1876
Affinity Capture-MS Homo sapiens
31 NUDT3 11165
Affinity Capture-MS Homo sapiens
32 HGS 9146
Affinity Capture-MS Homo sapiens
33 THAP11 57215
Affinity Capture-MS Homo sapiens
34 PLCG1 5335
Affinity Capture-MS Homo sapiens
35 THAP10  
Affinity Capture-MS Homo sapiens
36 APIP 51074
Affinity Capture-MS Homo sapiens
37 PHF11 51131
Affinity Capture-MS Homo sapiens
38 ZNF598 90850
Affinity Capture-MS Homo sapiens
39 DEFB106A  
Affinity Capture-MS Homo sapiens
40 IFNA4  
Affinity Capture-MS Homo sapiens
41 MYCN  
Affinity Capture-MS Homo sapiens
42 POU2F1 5451
Affinity Capture-MS Homo sapiens
43 CCNC  
Affinity Capture-MS Homo sapiens
44 C18orf21  
Affinity Capture-MS Homo sapiens
45 NDUFS5 4725
Affinity Capture-MS Homo sapiens
46 FEN1 2237
Affinity Capture-MS Homo sapiens
47 SLCO6A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 MPI 4351
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 EDC4 23644
Affinity Capture-MS Homo sapiens
51 ZNF550  
Affinity Capture-MS Homo sapiens
52 FCRL5  
Affinity Capture-MS Homo sapiens
53 SRRT 51593
Affinity Capture-MS Homo sapiens
54 DBNL 28988
Affinity Capture-MS Homo sapiens
55 UBE2T  
Affinity Capture-MS Homo sapiens
56 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
57 SFR1 119392
Affinity Capture-MS Homo sapiens
58 MYCBPAP 84073
Affinity Capture-MS Homo sapiens
59 NONO 4841
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 RNF115  
Affinity Capture-MS Homo sapiens
61 RTCA 8634
Affinity Capture-MS Homo sapiens
62 ASCL1  
Affinity Capture-MS Homo sapiens
63 ADH1C 126
Affinity Capture-MS Homo sapiens
64 CCDC51 79714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 FANCG 2189
Affinity Capture-MS Homo sapiens
66 YAP1 10413
Affinity Capture-MS Homo sapiens
67 PPP1R8 5511
Affinity Capture-MS Homo sapiens
68 NTRK1 4914
Affinity Capture-MS Homo sapiens
69 PIGT 51604
Affinity Capture-MS Homo sapiens
70 SCML2  
Affinity Capture-MS Homo sapiens
71 TEAD2  
Affinity Capture-MS Homo sapiens
72 UBP1 7342
Affinity Capture-MS Homo sapiens
73 SSUH2  
Affinity Capture-MS Homo sapiens
74 MID1IP1  
Affinity Capture-MS Homo sapiens
75 EIF4G2 1982
Affinity Capture-MS Homo sapiens
76 QKI 9444
Affinity Capture-MS Homo sapiens
77 HCN1  
Affinity Capture-MS Homo sapiens
78 APTX  
Affinity Capture-MS Homo sapiens
79 UPK1A 11045
Affinity Capture-MS Homo sapiens
80 DDX39B 7919
Affinity Capture-MS Homo sapiens
81 CSTF3 1479
Affinity Capture-MS Homo sapiens
82 B3GALNT1 8706
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 CYLD  
Affinity Capture-MS Homo sapiens
84 DKK2  
Affinity Capture-MS Homo sapiens
85 STAM 8027
Affinity Capture-MS Homo sapiens
86 SARAF  
Affinity Capture-MS Homo sapiens
87 ST8SIA1  
Affinity Capture-MS Homo sapiens
88 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
89 NDST2  
Affinity Capture-MS Homo sapiens
90 FANCD2  
Affinity Capture-MS Homo sapiens
91 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
92 AGPAT1 10554
Affinity Capture-MS Homo sapiens
93 NT5C1A  
Affinity Capture-MS Homo sapiens
94 DNM3 26052
Affinity Capture-MS Homo sapiens
95 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 ITLN2  
Affinity Capture-MS Homo sapiens
97 MOGAT3  
Affinity Capture-MS Homo sapiens
98 CD274 29126
Affinity Capture-MS Homo sapiens
99 PCP4  
Affinity Capture-MS Homo sapiens
100 ZSCAN12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 UNG  
Affinity Capture-MS Homo sapiens
102 NPPA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 RPRD1A  
Affinity Capture-MS Homo sapiens
104 ZC3HC1  
Affinity Capture-MS Homo sapiens
105 TBPL1 9519
Affinity Capture-MS Homo sapiens
106 RBFOX1 54715
Affinity Capture-MS Homo sapiens
107 PTK2 5747
Affinity Capture-MS Homo sapiens
108 FTH1 2495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 PLD5  
Affinity Capture-MS Homo sapiens
110 SNX27 81609
Affinity Capture-MS Homo sapiens
111 C21orf59 56683
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 SCYL2 55681
Affinity Capture-MS Homo sapiens
113 HES4  
Affinity Capture-MS Homo sapiens
114 GPANK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 FAM122B  
Affinity Capture-MS Homo sapiens
116 PI4KAP1  
Affinity Capture-MS Homo sapiens
117 XRCC6 2547
Proximity Label-MS Homo sapiens
118 DNM1L 10059
Affinity Capture-MS Homo sapiens
119 ALDH3A1 218
Affinity Capture-MS Homo sapiens
120 PLCZ1  
Affinity Capture-MS Homo sapiens
121 BMI1  
Affinity Capture-MS Homo sapiens
122 GMCL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 MRPL38  
Affinity Capture-MS Homo sapiens
124 SLC37A4 2542
Affinity Capture-MS Homo sapiens
125 STX17 55014
Affinity Capture-MS Homo sapiens
126 RIPPLY3  
Affinity Capture-MS Homo sapiens
127 QRICH1  
Affinity Capture-MS Homo sapiens
128 PRSS16 10279
Affinity Capture-MS Homo sapiens
129 FGL1  
Affinity Capture-MS Homo sapiens
130 SNCA 6622
Biochemical Activity Homo sapiens
131 GLS 2744
Affinity Capture-MS Homo sapiens
132 FNBP4  
Affinity Capture-MS Homo sapiens
133 GIGYF2 26058
Affinity Capture-MS Homo sapiens
134 FAM153B  
Affinity Capture-MS Homo sapiens
135 SLX4  
Affinity Capture-MS Homo sapiens
136 SLC25A6 293
Affinity Capture-MS Homo sapiens
137 AMTN  
Affinity Capture-MS Homo sapiens
138 SEC23IP 11196
Affinity Capture-MS Homo sapiens
139 TP53 7157
Affinity Capture-MS Homo sapiens
140 THUMPD3 25917
Affinity Capture-MS Homo sapiens
141 SH2D3A  
Affinity Capture-MS Homo sapiens
142 DDX3X 1654
Affinity Capture-MS Homo sapiens
143 ZNF154  
Affinity Capture-MS Homo sapiens
144 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 C1orf35  
Affinity Capture-MS Homo sapiens
146 NELFA  
Affinity Capture-MS Homo sapiens
147 QSER1  
Affinity Capture-MS Homo sapiens
148 PTDSS1 9791
Affinity Capture-MS Homo sapiens
149 KLHL11  
Affinity Capture-MS Homo sapiens
150 RAVER1 125950
Affinity Capture-MS Homo sapiens
151 ERCC3  
Affinity Capture-MS Homo sapiens
152 MBNL1 4154
Affinity Capture-MS Homo sapiens
153 THAP4 51078
Affinity Capture-MS Homo sapiens
154 KDELR2 11014
Affinity Capture-MS Homo sapiens
155 TEFM  
Affinity Capture-MS Homo sapiens
156 AIRE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
157 TSPAN6 7105
Affinity Capture-MS Homo sapiens
158 PINK1  
Affinity Capture-MS Homo sapiens
159 GOT1 2805
Affinity Capture-MS Homo sapiens
160 STK11 6794
Affinity Capture-MS Homo sapiens
161 ZUFSP 221302
Affinity Capture-MS Homo sapiens
162 PDE4DIP 9659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
163 Ttk  
Affinity Capture-MS Mus musculus
164 OR2A4 79541
Affinity Capture-MS Homo sapiens
165 GABPA 2551
Affinity Capture-MS Homo sapiens
166 CCR1  
Affinity Capture-MS Homo sapiens
167 CSGALNACT1 55790
Affinity Capture-MS Homo sapiens
168 GALNT9  
Affinity Capture-MS Homo sapiens
169 MSTO1 55154
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TGM1 is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
Formation of the cornified envelope TAS Reactome
Keratinization TAS Reactome





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